PDF(Pubmed)
Abstract：
UNASSIGNED: Laparoscopic proximal gastrectomy with double-tract reconstruction (LPG-DTR) expectedly results in improved nutritional status and less body weight loss than conventional total gastrectomy in upper-third gastric cancer. This study aimed to investigate the food passage patterns following LPG-DTR and its effect on nutritional outcomes up to 1 year after surgery.
UNASSIGNED: This prospective cohort study recruited 10 patients with early gastric cancer scheduled for LPG-DTR. Nutritional indices and body composition were assessed every 3 months up to 12 months. Liquid and solid food transits were evaluated with fluoroscopic upper gastrointestinal study and radionuclide scintigraphy, respectively.
UNASSIGNED: At 12 months, patients exhibited a body weight loss of 14.5% ± 3.6%. The main passage routes for liquid and solid foods differed, primarily via the interposed jejunum for liquids, whereas via both tracts for solids. The median half-life of solid food emptying from the remnant distal stomach was 105.1 minutes (range, 50.8-2,194.2 minutes), and duodenal passage of solid food was noted in 9 of 10 patients. Those with gastric half-emptying time >3 hours demonstrated greater weight loss (19.5% ± 1.4% vs. 12.5% ± 1.1%, P = 0.024) and more pronounced reduction in serum albumin levels (-0.5 ± 0.3 g/dL vs. 0.0 ± 0.2 g/dL, P = 0.024) after 12 months.
UNASSIGNED: LPG-DTR demonstrated varying food passage patterns depending on the food contents and delayed solid food emptying from the remnant stomach was associated with more substantial weight loss.
UNASSIGNED: This prospective cohort study recruited 10 patients with early gastric cancer scheduled for LPG-DTR. Nutritional indices and body composition were assessed every 3 months up to 12 months. Liquid and solid food transits were evaluated with fluoroscopic upper gastrointestinal study and radionuclide scintigraphy, respectively.
UNASSIGNED: At 12 months, patients exhibited a body weight loss of 14.5% ± 3.6%. The main passage routes for liquid and solid foods differed, primarily via the interposed jejunum for liquids, whereas via both tracts for solids. The median half-life of solid food emptying from the remnant distal stomach was 105.1 minutes (range, 50.8-2,194.2 minutes), and duodenal passage of solid food was noted in 9 of 10 patients. Those with gastric half-emptying time >3 hours demonstrated greater weight loss (19.5% ± 1.4% vs. 12.5% ± 1.1%, P = 0.024) and more pronounced reduction in serum albumin levels (-0.5 ± 0.3 g/dL vs. 0.0 ± 0.2 g/dL, P = 0.024) after 12 months.
UNASSIGNED: LPG-DTR demonstrated varying food passage patterns depending on the food contents and delayed solid food emptying from the remnant stomach was associated with more substantial weight loss.
摘要：
■腹腔镜近端胃切除术加双道重建术（LPG-DTR）在上三分之一胃癌中，与传统的全胃切除术相比，有望改善营养状况，减少体重减轻。这项研究旨在调查LPG-DTR后的食物通道模式及其对术后1年营养结果的影响。
■这项前瞻性队列研究招募了10名计划接受LPG-DTR的早期胃癌患者。每3个月至12个月评估营养指数和身体成分。通过荧光上消化道研究和放射性核素闪烁显像术评估了液体和固体食物的过境，分别。
■在12个月时，患者的体重减轻为14.5%±3.6%.液体和固体食品的主要通道不同，主要通过插入空肠的液体，而通过两个领域的固体。从残余远端胃排空固体食物的半衰期中位数为105.1分钟（范围，50.8-2,194.2分钟），10例患者中有9例出现十二指肠固体食物通道。那些胃半排空时间>3小时的患者表现出更大的体重减轻（19.5％±1.4％vs.12.5%±1.1%,P=0.024）和更明显的血清白蛋白水平降低（-0.5±0.3g/dLvs.0.0±0.2g/dL,12个月后P=0.024）。
■LPG-DTR显示出取决于食物含量的不同的食物通道模式，并且从残余胃中排空固体食物的延迟与更大量的体重减轻有关。
■这项前瞻性队列研究招募了10名计划接受LPG-DTR的早期胃癌患者。每3个月至12个月评估营养指数和身体成分。通过荧光上消化道研究和放射性核素闪烁显像术评估了液体和固体食物的过境，分别。
■在12个月时，患者的体重减轻为14.5%±3.6%.液体和固体食品的主要通道不同，主要通过插入空肠的液体，而通过两个领域的固体。从残余远端胃排空固体食物的半衰期中位数为105.1分钟（范围，50.8-2,194.2分钟），10例患者中有9例出现十二指肠固体食物通道。那些胃半排空时间>3小时的患者表现出更大的体重减轻（19.5％±1.4％vs.12.5%±1.1%,P=0.024）和更明显的血清白蛋白水平降低（-0.5±0.3g/dLvs.0.0±0.2g/dL,12个月后P=0.024）。
■LPG-DTR显示出取决于食物含量的不同的食物通道模式，并且从残余胃中排空固体食物的延迟与更大量的体重减轻有关。
