PDF(Pubmed)
Abstract：
The brain potential known as mismatch negativity (MMN) is one of the most studied indices of altered brain function in schizophrenia. This review looks at what has been learned about MMN in schizophrenia over the last three decades and why the level of interest and activity in this field of research remains strong. A diligent consideration of available evidence suggests that MMN can serve as a biomarker in schizophrenia, but perhaps not the kind of biomarker that early research supposed. This review concludes that MMN measurement is likely to be most useful as a monitoring and response biomarker enabling tracking of an underlying pathology and efficacy of interventions, respectively. The role of, and challenges presented by, pre-clinical models is discussed as well as the merits of different methodologies that can be brought to bear in pursuing a deeper understanding of pathophysiology that might explain smaller MMN in schizophrenia.
摘要：
被称为失配负性（MMN）的脑电位是精神分裂症中脑功能改变的研究最多的指标之一。这篇综述着眼于在过去三十年中对精神分裂症中MMN的了解，以及为什么在这一研究领域的兴趣和活动水平仍然很高。对现有证据的认真考虑表明，MMN可以作为精神分裂症的生物标志物，但也许不是早期研究认为的生物标志物。这篇综述得出结论，MMN测量可能是最有用的监测和响应生物标志物，能够跟踪潜在的病理和干预措施的疗效。分别。的作用,以及所带来的挑战，讨论了临床前模型以及不同方法的优点，这些方法可以在对病理生理学进行更深入的了解时发挥作用，这些病理生理学可能解释精神分裂症中较小的MMN。
