PDF(Pubmed)
Abstract：
BACKGROUND: Maintaining venous access is of great clinical importance. Running a slow continuous infusion to keep the vein open (KVO) is often used in peripheral intravenous catheters (PIVCs). Previous studies have compared the effects of intermittent flushing and continuous infusion via peripherally inserted central catheters (PICCs). In this study, we applied KVO to central venous catheters (CVCs) and compared the occlusion rate of this technique with that of the intermittent flushing technique.
METHODS: This is a randomized controlled trial of 14 hospitals in China. A total of 250 patients will be recruited in this study, and they will be randomized at a 1:1 ratio. After study inclusion, patients who will undergo CVC insertion will receive intermittent flushing with prefilled saline syringes (control group) or KVO infusion with elastic pumps (test group). All the catheters will be checked for patency by scoping Catheter Injection and Aspiration (CINAS) Classification on Days 3 and 7. The primary outcome is the rate of catheter occlusion in 7 days. Patients will be followed up until 9 days after CVC insertion, catheter occlusion, or catheter removal. The secondary outcomes are the rate of catheter occlusion in 3 days, nurse satisfaction, cost-effectiveness, adverse event rate, catheter-related bloodstream infection rate, catheter-related thrombosis rate, extravasation rate, phlebitis rate, and catheter migration.
CONCLUSIONS: We expect that the trial will generate findings that can provide an evidence-based basis for the improvement and optimization of clinical catheter flushing techniques.
BACKGROUND: Chinese Clinical Trial Registry, ChiCTR2200064007. Registered on 23 September 2022. https://www.chictr.org.cn/showproj.html?proj=177311 .
METHODS: This is a randomized controlled trial of 14 hospitals in China. A total of 250 patients will be recruited in this study, and they will be randomized at a 1:1 ratio. After study inclusion, patients who will undergo CVC insertion will receive intermittent flushing with prefilled saline syringes (control group) or KVO infusion with elastic pumps (test group). All the catheters will be checked for patency by scoping Catheter Injection and Aspiration (CINAS) Classification on Days 3 and 7. The primary outcome is the rate of catheter occlusion in 7 days. Patients will be followed up until 9 days after CVC insertion, catheter occlusion, or catheter removal. The secondary outcomes are the rate of catheter occlusion in 3 days, nurse satisfaction, cost-effectiveness, adverse event rate, catheter-related bloodstream infection rate, catheter-related thrombosis rate, extravasation rate, phlebitis rate, and catheter migration.
CONCLUSIONS: We expect that the trial will generate findings that can provide an evidence-based basis for the improvement and optimization of clinical catheter flushing techniques.
BACKGROUND: Chinese Clinical Trial Registry, ChiCTR2200064007. Registered on 23 September 2022. https://www.chictr.org.cn/showproj.html?proj=177311 .
摘要：
背景：维持静脉通路具有重要的临床意义。在外周静脉导管(PIVC)中通常使用缓慢连续输注以保持静脉开放(KVO)。先前的研究比较了通过外周插入的中央导管（PICCs）间歇性冲洗和连续输注的效果。在这项研究中,我们将KVO应用于中心静脉导管(CVC),并比较了该技术与间歇冲洗技术的闭塞率.
方法：这是一项中国14家医院的随机对照试验。这项研究将招募250名患者，他们将以1:1的比例随机化。纳入研究后，将接受CVC插入的患者将接受用预充式盐水注射器间歇冲洗(对照组)或用弹性泵输注KVO(试验组).在第3天和第7天,通过检查导管注射和抽吸(CINAS)分类来检查所有导管的通畅性。主要结果是7天内导管闭塞率。将对患者进行随访，直到CVC插入后9天，导管闭塞,或导管移除。次要结果是3天内导管闭塞率，护士满意度,成本效益，不良事件发生率,导管相关血流感染率,导管相关血栓形成率，外渗率,静脉炎发生率,和导管迁移。
结论：我们希望该试验将产生可为临床导管冲洗技术的改进和优化提供循证依据的发现。
背景：中国临床试验注册中心，ChiCTR2200064007。2022年9月23日注册。https://www.chictr.org.cn/showproj.html?proj=177311。
方法：这是一项中国14家医院的随机对照试验。这项研究将招募250名患者，他们将以1:1的比例随机化。纳入研究后，将接受CVC插入的患者将接受用预充式盐水注射器间歇冲洗(对照组)或用弹性泵输注KVO(试验组).在第3天和第7天,通过检查导管注射和抽吸(CINAS)分类来检查所有导管的通畅性。主要结果是7天内导管闭塞率。将对患者进行随访，直到CVC插入后9天，导管闭塞,或导管移除。次要结果是3天内导管闭塞率，护士满意度,成本效益，不良事件发生率,导管相关血流感染率,导管相关血栓形成率，外渗率,静脉炎发生率,和导管迁移。
结论：我们希望该试验将产生可为临床导管冲洗技术的改进和优化提供循证依据的发现。
背景：中国临床试验注册中心，ChiCTR2200064007。2022年9月23日注册。https://www.chictr.org.cn/showproj.html?proj=177311。
