Abstract：
Erythritol, as a new type of natural sweetener, has been widely used in food, medical, cosmetics, pharmaceutical and other fields due to its unique physical and chemical properties and physiological functions. In recent years, with the continuous development of strategies such as synthetic biology, metabolic engineering, omics-based systems biology and high-throughput screening technology, people\'s understanding of the erythritol biosynthesis pathway has gradually deepened, and microbial cell factories with independent modification capabilities have been successfully constructed. In this review, the cheap feedstocks for erythritol synthesis are introduced in detail, the environmental factors affecting the synthesis of erythritol and its regulatory mechanism are described, and the tools and strategies of metabolic engineering involved in erythritol synthesis are summarized. In addition, the study of erythritol derivatives is helpful in expanding its application field. Finally, the challenges that hinder the effective production of erythritol are discussed, which lay a foundation for the green, efficient and sustainable production of erythritol in the future and breaking through the bottleneck of production.
摘要：
赤藓糖醇,作为一种新型的天然甜味剂，已广泛用于食品中，medical,化妆品,制药等领域由于其独特的理化性质和生理功能。近年来,随着合成生物学等战略的不断发展，代谢工程,基于组学的系统生物学和高通量筛选技术，人们对赤藓糖醇生物合成途径的认识逐渐加深,和具有独立修饰能力的微生物细胞工厂已经成功建设。在这次审查中,详细介绍了合成赤藓糖醇的廉价原料，阐述了影响赤藓糖醇合成的环境因素及其调控机制,综述了赤藓糖醇合成中代谢工程的工具和策略。此外,赤藓糖醇衍生物的研究有助于拓展其应用领域。最后,讨论了阻碍赤藓糖醇有效生产的挑战，为绿色奠定了基础，未来赤藓糖醇的高效可持续生产,突破生产瓶颈。
