发现具有有利的药代动力学特征和体内抗癌功效的 CDC42 抑制剂。
Mesh : Animals Antineoplastic Agents / pharmacokinetics pharmacology chemistry Humans Mice cdc42 GTP-Binding Protein / antagonists & inhibitors metabolism Cell Line, Tumor Drug Discovery Structure-Activity Relationship Xenograft Model Antitumor Assays Pyrimidines / pharmacokinetics chemistry pharmacology chemical synthesis Female
来 源:
DOI:10.1021/acs.jmedchem.4c00855
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