Abstract：
Bacterial lipopolysaccharide (LPS) is implicated in disrupting the blood-brain barrier (BBB). In a recent issue of Nature, Wei et al. now show that LPS activates the inflammatory caspases (4, 5, and 11) and gasdermin D (GSDMD) in brain endothelial cells, which triggers their pyroptotic cell death and disrupts the BBB.
摘要：
细菌脂多糖（LPS）与破坏血脑屏障（BBB）有关。在最近一期的《自然》杂志上，魏等人。现在显示LPS激活脑内皮细胞中的炎性半胱天冬酶（4、5和11）和gasderminD（GSDMD），这触发了它们的焦转细胞死亡并破坏了BBB。
