PDF(Pubmed)
Abstract：
RAS guanyl releasing protein 1 (RASGRP1) is a guanine nucleotide exchange factor (GEF) characterized by the presence of a RAS superfamily GEF domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor, specifically activating RAS through the exchange of bound GDP for GTP. Activation of RAS by RASGRP1 has a wide range of downstream effects at the cellular level. Thus, it is not surprising that many diseases are associated with RASGRP1 disorders. Here, we present an overview of the structure and function of RASGRP1, its crucial role in the development, expression, and regulation of immune cells, and its involvement in various signaling pathways. This review comprehensively explores the relationship between RASGRP1 and various diseases, elucidates the underlying molecular mechanisms of RASGRP1 in each disease, and identifies potential therapeutic targets. This study provides novel insights into the role of RASGRP1 in insulin secretion and highlights its potential as a therapeutic target for diabetes. The limitations and challenges associated with studying RASGRP1 in disease are also discussed.
摘要：
RAS鸟苷酸释放蛋白1(RASGRP1)是鸟嘌呤核苷酸交换因子(GEF),其特征在于存在RAS超家族GEF结构域。它作为二酰甘油（DAG）调节的核苷酸交换因子，特别是通过将绑定GDP交换为GTP来激活RAS。RASGRP1对RAS的激活在细胞水平上具有广泛的下游效应。因此，许多疾病与RASGRP1疾病相关也就不足为奇了.这里,我们概述了RASGRP1的结构和功能，它在发展中的关键作用，表达式,和调节免疫细胞，以及它参与各种信号通路。本文综合探讨了RASGRP1与各种疾病的关系,阐明RASGRP1在每种疾病中的潜在分子机制，并确定潜在的治疗目标。这项研究为RASGRP1在胰岛素分泌中的作用提供了新的见解，并强调了其作为糖尿病治疗靶标的潜力。还讨论了与在疾病中研究RASGRP1相关的局限性和挑战。
