Abstract：
The repair of infected wounds is a complex physiopathologic process. Current studies on infected wound treatment have predominantly focused on infection treatment, while the factors related to delayed healing caused by vascular damage and immune imbalance are commonly overlooked. In this study, an extracellular matrix (ECM)-like dynamic and multifunctional hyaluronic acid (HA) hydrogel with antimicrobial, immunomodulatory, and angiogenic capabilities was designed as wound dressing for the treatment of infected skin wounds. The dynamic network in the hydrogel dressing was based on reversible metal-ligand coordination formed between sulfhydryl groups and bioactive metal ions. In our design, antibacterial silver and immunomodulatory zinc ions were employed to coordinate with sulfhydrylated HA and a vasculogenic peptide. In addition to the desired bioactivities for infected wounds, the hydrogel could also exhibit self-healing and injectable abilities. Animal experiments with infected skin wound models indicated that the hydrogel dressings enabled minimally invasive injection and seamless skin wound covering and then facilitated wound healing by efficient bacterial killing, continuous inflammation inhibition, and improved blood vessel formation. In conclusion, the metal ion-coordinated hydrogels with wound-infection-desired bioactivities and ECM-like dynamic structures represent a class of tissue bionic wound dressings for the treatment of infected and chronic inflammation wounds.
摘要：
感染伤口的修复是一个复杂的病理生理过程。目前关于感染伤口治疗的研究主要集中在感染治疗上。而血管损伤和免疫失衡引起的延迟愈合的相关因素却普遍被忽视。在这项研究中,细胞外基质（ECM）样动态和多功能透明质酸（HA）水凝胶，免疫调节,血管生成能力被设计为伤口敷料，用于治疗感染的皮肤伤口。水凝胶敷料中的动态网络基于巯基和生物活性金属离子之间形成的可逆金属-配体配位。在我们的设计中，抗菌银和免疫调节锌离子用于与巯基化HA和血管生成肽协调。除了感染伤口所需的生物活性外，水凝胶还可以表现出自我修复和可注射的能力。感染皮肤伤口模型的动物实验表明，水凝胶敷料能够实现微创注射和无缝皮肤伤口覆盖，然后通过有效的细菌杀灭促进伤口愈合。持续的炎症抑制，改善血管形成。总之,具有伤口感染所需的生物活性和ECM样动态结构的金属离子配位水凝胶代表了一类用于治疗感染和慢性炎症伤口的组织仿生伤口敷料。
