Abstract：
BACKGROUND: This study aimed to evaluate the blood pressure (BP) status, including arterial stiffness parameters, hemodynamic indicators, circadian profile, and its association with albuminuria in adolescents with type 1 diabetes mellitus (DM1).
METHODS: The analysis included 46 patients, with diabetes duration of 7.38 ± 3.48 years. Ambulatory blood pressure monitoring (ABPM) was conducted using an oscillometric device, the Mobil-O-Graph, which is a Pulse Wave Analysis Monitor.
RESULTS: Hypertension (HT) was diagnosed in 31 adolescents (67% of patients), primarily due to isolated nocturnal BP (21 cases, 68% of HT cases). The HT group exhibited significantly increased diastolic load (DL). Pulse wave velocity (PWV, a measure of arterial stiffness) values showed a strong correlation with both peripheral systolic BP (r = 0.954) and central systolic BP (r = 0.838). Additionally, non-dipping status was found in 61% of the HT group. Urinary albumin excretion (UAE) was positively correlated with diastolic BP (particularly nocturnal) peripheral and central BP, DL, heart rate, augmentation index (AIx@75), and nocturnal total vascular resistance (TVR). Diastolic non-dippers exhibited a significant increase in UAE.
CONCLUSIONS: Hypertension is a common complication in adolescents with type 1 diabetes mellitus, primarily caused by elevated nocturnal diastolic BP. Albuminuria is mainly associated with diastolic BP, especially during the nocturnal period and in cases of diastolic non-dipping status. The association of UAE with AIx@75 and nocturnal TVR suggests the presence of early-stage vascular disease in diabetic adolescents.
METHODS: The analysis included 46 patients, with diabetes duration of 7.38 ± 3.48 years. Ambulatory blood pressure monitoring (ABPM) was conducted using an oscillometric device, the Mobil-O-Graph, which is a Pulse Wave Analysis Monitor.
RESULTS: Hypertension (HT) was diagnosed in 31 adolescents (67% of patients), primarily due to isolated nocturnal BP (21 cases, 68% of HT cases). The HT group exhibited significantly increased diastolic load (DL). Pulse wave velocity (PWV, a measure of arterial stiffness) values showed a strong correlation with both peripheral systolic BP (r = 0.954) and central systolic BP (r = 0.838). Additionally, non-dipping status was found in 61% of the HT group. Urinary albumin excretion (UAE) was positively correlated with diastolic BP (particularly nocturnal) peripheral and central BP, DL, heart rate, augmentation index (AIx@75), and nocturnal total vascular resistance (TVR). Diastolic non-dippers exhibited a significant increase in UAE.
CONCLUSIONS: Hypertension is a common complication in adolescents with type 1 diabetes mellitus, primarily caused by elevated nocturnal diastolic BP. Albuminuria is mainly associated with diastolic BP, especially during the nocturnal period and in cases of diastolic non-dipping status. The association of UAE with AIx@75 and nocturnal TVR suggests the presence of early-stage vascular disease in diabetic adolescents.
摘要：
背景：本研究旨在评估血压（BP）状态，包括动脉僵硬度参数，血液动力学指标,昼夜节律，及其与青少年1型糖尿病（DM1）蛋白尿的相关性。
方法：分析包括46例患者，糖尿病病程为7.38±3.48年。使用示波装置进行动态血压监测（ABPM），Mobil-O-Graph,这是一个脉搏波分析监视器。
结果：在31名青少年（占患者的67％）中诊断出高血压（HT），主要是由于孤立的夜间血压(21例，68%的HT病例)。HT组的舒张负荷（DL）明显增加。脉搏波速度(PWV,动脉僵硬度的度量）值显示与外周收缩压BP（r=0.954）和中心收缩压BP（r=0.838）均有很强的相关性。此外,61％的HT组处于非浸渍状态。尿白蛋白排泄量(UAE)与舒张压(尤其是夜间)外周和中枢BP呈正相关,DL,心率,增强指数(AIX@75)，和夜间总血管阻力（TVR）。非扩张型非扩张型在阿联酋表现出显着增加。
结论：高血压是青少年1型糖尿病的常见并发症，主要由夜间舒张压升高引起。白蛋白尿主要与舒张压有关，尤其是在夜间和舒张非浸渍状态的情况下。UAE与AIx@75和夜间TVR的关联提示糖尿病青少年存在早期血管疾病。
方法：分析包括46例患者，糖尿病病程为7.38±3.48年。使用示波装置进行动态血压监测（ABPM），Mobil-O-Graph,这是一个脉搏波分析监视器。
结果：在31名青少年（占患者的67％）中诊断出高血压（HT），主要是由于孤立的夜间血压(21例，68%的HT病例)。HT组的舒张负荷（DL）明显增加。脉搏波速度(PWV,动脉僵硬度的度量）值显示与外周收缩压BP（r=0.954）和中心收缩压BP（r=0.838）均有很强的相关性。此外,61％的HT组处于非浸渍状态。尿白蛋白排泄量(UAE)与舒张压(尤其是夜间)外周和中枢BP呈正相关,DL,心率,增强指数(AIX@75)，和夜间总血管阻力（TVR）。非扩张型非扩张型在阿联酋表现出显着增加。
结论：高血压是青少年1型糖尿病的常见并发症，主要由夜间舒张压升高引起。白蛋白尿主要与舒张压有关，尤其是在夜间和舒张非浸渍状态的情况下。UAE与AIx@75和夜间TVR的关联提示糖尿病青少年存在早期血管疾病。
