%0 Journal Article
%T Ambulatory blood pressure parameters and their association with albuminuria in adolescents with type 1 diabetes mellitus.
%A Sołtysiak J
%A Skowrońska B
%A Maćkowiak-Lewandowicz K
%A Blumczyński A
%A Elżbieta K
%A Ostalska-Nowicka D
%A Zachwieja J
%J Pediatr Nephrol
%V 0
%N 0
%D 2024 Jun 12
%M 38864872
%F 3.651
%R 10.1007/s00467-024-06416-3
%X <B>BACKGROUND: </B>This study aimed to evaluate the blood pressure (BP) status, including arterial stiffness parameters, hemodynamic indicators, circadian profile, and its association with albuminuria in adolescents with type 1 diabetes mellitus (DM1).<BR><B>METHODS: </B>The analysis included 46 patients, with diabetes duration of 7.38 ± 3.48 years. Ambulatory blood pressure monitoring (ABPM) was conducted using an oscillometric device, the Mobil-O-Graph, which is a Pulse Wave Analysis Monitor.<BR><B>RESULTS: </B>Hypertension (HT) was diagnosed in 31 adolescents (67% of patients), primarily due to isolated nocturnal BP (21 cases, 68% of HT cases). The HT group exhibited significantly increased diastolic load (DL). Pulse wave velocity (PWV, a measure of arterial stiffness) values showed a strong correlation with both peripheral systolic BP (r = 0.954) and central systolic BP (r = 0.838). Additionally, non-dipping status was found in 61% of the HT group. Urinary albumin excretion (UAE) was positively correlated with diastolic BP (particularly nocturnal) peripheral and central BP, DL, heart rate, augmentation index (AIx@75), and nocturnal total vascular resistance (TVR). Diastolic non-dippers exhibited a significant increase in UAE.<BR><B>CONCLUSIONS: </B>Hypertension is a common complication in adolescents with type 1 diabetes mellitus, primarily caused by elevated nocturnal diastolic BP. Albuminuria is mainly associated with diastolic BP, especially during the nocturnal period and in cases of diastolic non-dipping status. The association of UAE with AIx@75 and nocturnal TVR suggests the presence of early-stage vascular disease in diabetic adolescents.