Abstract：
This case report aims to present the findings of in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT) in three patients with iridocorneal endothelial (ICE) syndrome. Three female patients 37, 50, and 57 years of age presented with complaints of unilateral visual impairment and elevated intraocular pressure (IOP). Biomicroscopy revealed unilateral pupil irregularities and anterior synechiae, and gonioscopy demonstrated synechiae in the iridocorneal angle. IOP was within normal limits with medical treatment in two patients, while one patient had an IOP of 44 mmHg despite maximal antiglaucomatous treatment. IVCM revealed large, polymorphic, and hyperreflective cells in the corneal endothelial layer of the affected eyes and normal corneal epithelium, stroma, and endothelium in the fellow eyes. AS-OCT findings were normal in healthy eyes, while the affected eye showed synechiae in the iridocorneal angle and a hyperreflective, thickened endothelial layer. The patient with refractory glaucoma underwent trabeculectomy surgery with 5-fluorouracil. In conclusion, IVCM and AS-OCT allow a detailed examination of endothelial cell abnormalities and iridocorneal membranes in ICE syndrome, which is characterized by unilateral pupil and iris irregularities and anterior synechiae mainly in women.
摘要：
本病例报告旨在介绍3例虹膜角膜内皮（ICE）综合征患者的体内共聚焦显微镜（IVCM）和眼前节光学相干断层扫描（AS-OCT）的发现。三名年龄分别为37、50和57岁的女性患者表现出单侧视力障碍和眼内压（IOP）升高的抱怨。生物显微镜检查显示单侧瞳孔不规则和前粘连，和房角镜检查显示虹膜角膜角粘连。两名患者接受药物治疗后眼压在正常范围内，尽管进行了最大程度的抗青光眼治疗，但一名患者的IOP为44mmHg。IVCM显示很大，多态,和受影响的眼睛和正常角膜上皮的角膜内皮层中的高反射细胞，基质,和其他人眼中的内皮。健康眼睛的AS-OCT检查结果正常,虽然受影响的眼睛在虹膜角膜角度和过度反射显示粘连，内皮层增厚。难治性青光眼患者接受了5-氟尿嘧啶小梁切除术。总之,IVCM和AS-OCT可以详细检查ICE综合征的内皮细胞异常和虹膜角膜膜，主要表现为女性单侧瞳孔和虹膜不规则和前粘连。
