Abstract：
In this study, we investigated the ameliorative gut modulatory effect of carboxymethylated Lycium barbarum seed dreg insoluble dietary fiber (LBSDIDF) on hyperlipidemic mice. After seven weeks of insoluble dietary fiber (IDF) intervention, the results demonstrated that IDFs effectively inhibited body weight gain, with slimming and hypolipidemic effects, and improved liver histopathology by decreasing ALT, AST, TNF-α and IL-6, and increasing short-chain fatty acid (SCFA) levels in hyperlipidemic mice. With the increasing diversity and abundance of intestinal bacteria and decreasing ratio of Firmicutes to Bacteroidetes, intestinal flora facilitated cholesterol lowering effects in hyperlipidemic mice. Our research offers a novel concept for the use of LBSDIDF as a prebiotic to improve intestinal dysbiosis or as a preventive measure against obesity and dyslipidemia.
摘要：
在这项研究中,我们研究了羧甲基化枸杞种子不溶性膳食纤维（LBSDIDF）对高脂血症小鼠的肠道调节作用。经过7周的不溶性膳食纤维（IDF）干预，结果表明，IDFs有效地抑制了体重增加，具有减肥和降血脂作用，并通过降低ALT改善肝脏组织病理学，AST,TNF-α和IL-6，并增加高脂血症小鼠的短链脂肪酸（SCFA）水平。随着肠道细菌多样性和丰度的增加，厚壁菌与拟杆菌的比例降低，肠道菌群促进高脂血症小鼠的降胆固醇作用。我们的研究为使用LBSDIDF作为益生元改善肠道生态失调或预防肥胖和血脂异常提供了新的概念。
