Abstract：
The most significant contributor to global mortality are cardiovascular diseases. Dietary factors significantly impact the risk, advancement, and treatment of cardiometabolic conditions. Chocolate, known for its adaptability and capacity to stimulate pleasure centers, emerges as a promising vehicle for integrating different bioactive elements. This systematic review analyzed 10 randomized controlled trials investigating the health effects of consuming enriched, fortified, or supplemented chocolate. These trials varied in chocolate intake amounts (ranging from 5 to 101 g day-1), incorporated bioactive components (co-crystalized astaxanthin, lycopene, wood-based phytosterol-phytostanol mixture, canola sterol esters, etc.), and duration (from 2 weeks to 1 year). Some enriched chocolates were found to reduce total and LDL cholesterol and influence markers of oxidative damage, inflammation, immune function, and skin parameters. However, certain trials showed a minimal impact on health outcomes. Therefore, while enriched chocolate holds promise as a carrier for beneficial bioactive compounds, rigorous scientific inquiry and methodological rigor are crucial to fully substantiate these claims. Comprehensive evaluations covering cardiovascular health, metabolic function, immune response, and other aspects are needed to understand its potential benefits and limitations. Advancing robust research initiatives could help realize the full potential of enriched chocolate in promoting human health and well-being.
摘要：
全球死亡率的最重要因素是心血管疾病。饮食因素显著影响风险，进步,和心脏代谢疾病的治疗。巧克力,以其适应性和刺激快乐中心的能力而闻名，成为整合不同生物活性元素的有前途的载体。这项系统评价分析了10项随机对照试验，调查了食用丰富的健康影响，强化，或补充巧克力。这些试验的巧克力摄入量各不相同(范围从5到101克day-1)，掺入的生物活性成分(共晶虾青素，番茄红素,木质植物甾醇-植物甾烷醇混合物，油菜甾醇酯，等。),和持续时间（从2周到1年）。发现一些富含巧克力可以降低总胆固醇和LDL胆固醇，并影响氧化损伤的标志物。炎症,免疫功能，和皮肤参数。然而,某些试验显示对健康结局的影响最小.因此,虽然浓缩巧克力有望成为有益生物活性化合物的载体，严格的科学探究和方法严谨对于充分证实这些主张至关重要。涵盖心血管健康的综合评估，代谢功能，免疫反应，和其他方面需要了解其潜在的好处和局限性。推进强有力的研究举措可以帮助实现丰富巧克力在促进人类健康和福祉方面的全部潜力。
