Abstract：
UNASSIGNED: Youth with neurofibromatosis type I (NF1) demonstrate high rates of Autism Spectrum Disorder (ASD) and Attention Deficit/Hyperactivity Disorder (ADHD), which often have overlapping behaviors. Diagnostic clarity is important to guide services. This study evaluated ASD classification in NF1 using various methods and whether those with ADHD suspicion have more social challenges associated with ASD.
UNASSIGNED: 34 youth with NF1 (Mage = 10.5 ± 1.6 years), completed ASD assessments that combined direct observation and informant ratings to yield a Clinician Best Estimate (CBE) classification. Caregivers rated ASD-related social challenges using the Social Responsiveness Scale- 2nd Edition (SRS-2).
UNASSIGNED: ASD classification varied depending on the method, ranging from 32% using low-threshold SRS-2 cut-scores (T ≥ 60) to under 6% when combining cut scores for diagnostic observational tools and stringent SRS-2 cut-scores (T ≥ 70). 14.7% had a CBE ASD classification. 44% were judged to have autism traits associated with a non-ASD diagnosis. The 52.9% with a suspicion of ADHD had higher SRS-2 scores than those without ADHD, F (7, 26) = 3.45, p < .05, Wilk\'s lambda = 0.518, partial eta squared = 0.482.
UNASSIGNED: Findings highlight the importance of rigorous diagnostic methodology when evaluating ASD in NF1 to inform the selection of targeted interventions for socialization challenges in NF1.
UNASSIGNED: 34 youth with NF1 (Mage = 10.5 ± 1.6 years), completed ASD assessments that combined direct observation and informant ratings to yield a Clinician Best Estimate (CBE) classification. Caregivers rated ASD-related social challenges using the Social Responsiveness Scale- 2nd Edition (SRS-2).
UNASSIGNED: ASD classification varied depending on the method, ranging from 32% using low-threshold SRS-2 cut-scores (T ≥ 60) to under 6% when combining cut scores for diagnostic observational tools and stringent SRS-2 cut-scores (T ≥ 70). 14.7% had a CBE ASD classification. 44% were judged to have autism traits associated with a non-ASD diagnosis. The 52.9% with a suspicion of ADHD had higher SRS-2 scores than those without ADHD, F (7, 26) = 3.45, p < .05, Wilk\'s lambda = 0.518, partial eta squared = 0.482.
UNASSIGNED: Findings highlight the importance of rigorous diagnostic methodology when evaluating ASD in NF1 to inform the selection of targeted interventions for socialization challenges in NF1.
摘要：
■患有I型神经纤维瘤病（NF1）的年轻人表现出很高的自闭症谱系障碍（ASD）和注意力缺陷/多动障碍（ADHD），通常有重叠的行为。诊断清晰度对于指导服务很重要。这项研究使用各种方法评估了NF1中的ASD分类，以及怀疑患有ADHD的人是否有更多与ASD相关的社会挑战。
■拥有NF1的34名青年（法师=10.5±1.6岁），完成ASD评估，结合直接观察和线人评级，以产生临床医生最佳估计（CBE）分类。护理人员使用社会反应能力量表-第二版（SRS-2）对与ASD相关的社会挑战进行评分。
■ASD分类因方法而异，使用低阈值SRS-2切割评分(T≥60)的32%到将诊断性观察工具的切割评分和严格的SRS-2切割评分(T≥70)组合在一起时的6%以下。14.7%有CBEASD分类。44％的人被认为具有与非ASD诊断相关的自闭症特征。怀疑多动症的52.9%的人比没有多动症的人有更高的SRS-2评分，F(7,26)=3.45,p<.05,Wilkλ=0.518,部分eta平方=0.482。
■研究结果强调了严格的诊断方法在评估NF1中的ASD时的重要性，为NF1中的社会化挑战选择有针对性的干预措施提供信息。
■拥有NF1的34名青年（法师=10.5±1.6岁），完成ASD评估，结合直接观察和线人评级，以产生临床医生最佳估计（CBE）分类。护理人员使用社会反应能力量表-第二版（SRS-2）对与ASD相关的社会挑战进行评分。
■ASD分类因方法而异，使用低阈值SRS-2切割评分(T≥60)的32%到将诊断性观察工具的切割评分和严格的SRS-2切割评分(T≥70)组合在一起时的6%以下。14.7%有CBEASD分类。44％的人被认为具有与非ASD诊断相关的自闭症特征。怀疑多动症的52.9%的人比没有多动症的人有更高的SRS-2评分，F(7,26)=3.45,p<.05,Wilkλ=0.518,部分eta平方=0.482。
■研究结果强调了严格的诊断方法在评估NF1中的ASD时的重要性，为NF1中的社会化挑战选择有针对性的干预措施提供信息。
