PDF(Pubmed)
Abstract：
The spices and aromatic herbs were used not only in cooking to add flavour and smell to dishes but also for medicinal use. Nigella sativa, also called black cumin, is one of the species that contains an important bioactive component, thymoquinone (TQ), which has antioxidant, anti-inflammatory, antimicrobial, and antidiabetic effects. Curcuma longa, which also includes curcumin, has numerous anti-cancer properties. However, the bioavailability of curcumin is lower than that of its analogs. An analog of curcumin (EF-24), which has better bioavailability than curcumin, is capable of exerting a high anti-cancer effect. In our study, we determined the effects of PON1 enzyme activity on the proliferation and aggressiveness of glioblastoma cancer treated with TQ and EF-24 from lysates of the glioblastoma cell line U87MG. The results were determined as increased PON1 activity after treatment with TQ and EF-24 in the U87MG cell line (p < 0.0001).
摘要：
香料和芳香草药不仅用于烹饪，以增加菜肴的风味和气味，还用于药用。Nigellasativa,也叫黑孜然,是含有重要生物活性成分的物种之一，百里香醌(TQ),它有抗氧化剂，抗炎,抗菌，和抗糖尿病作用。姜黄,其中还包括姜黄素，具有多种抗癌特性。然而,姜黄素的生物利用度低于其类似物。姜黄素（EF-24）的类似物，比姜黄素具有更好的生物利用度，能够发挥高抗癌作用。在我们的研究中,我们确定了PON1酶活性对胶质母细胞瘤细胞系U87MG裂解物中TQ和EF-24治疗的胶质母细胞瘤癌症的增殖和侵袭性的影响。结果被确定为在U87MG细胞系中用TQ和EF-24处理后PON1活性增加(p<0.0001)。
