Abstract：
In this study, we investigated amylin-like substance distribution in the pancreas of Japanese quail (Coturnix japonica) using a specific anti-rat amylin serum. We detected amylin-immunoreactive cells dispersed in the pancreatic extra-islet region but not in the islet region. The synthetic rat amylin-containing serum pre-absorption abolished the staining profile. Almost all amylin-immunoreactive cells were immuno-positive for peptide YY (PYY). In addition, certain amylin-immunoreactive cells stained immuno-positive for glucagon. Amylin and PYY co-secreted from the extra-islet cells might participate in the insulin and glucagon release regulation in the pancreas and food intake modulation through the central nervous system.
摘要：
在这项研究中,我们使用特定的抗大鼠胰淀素血清研究了日本鹌鹑（Coturnixjaponica）胰腺中胰淀素样物质的分布。我们检测到胰淀素免疫反应性细胞分散在胰腺胰岛外区域而不是胰岛区域。合成的含胰淀素的大鼠血清预吸收消除了染色谱。几乎所有胰淀素免疫反应性细胞对肽YY(PYY)是免疫阳性的。此外,某些胰淀素免疫反应性细胞对胰高血糖素呈免疫阳性。胰岛外细胞分泌的胰淀素和PYY可能参与胰腺胰岛素和胰高血糖素的释放调节以及通过中枢神经系统调节食物摄入。
