PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to investigate the predictive value of the thyroid-stimulating hormone to high-density lipoprotein cholesterol ratio (THR) in identifying specific vulnerable carotid artery plaques.
UNASSIGNED: In this retrospective analysis, we included 76 patients with carotid plaques who met the criteria for admission to Zhejiang Hospital from July 2019 to June 2021. High-resolution magnetic resonance imaging (HRMRI) and the MRI-PlaqueView vascular plaque imaging diagnostic system were utilized to analyze carotid artery images for the identification of specific plaque components, including the lipid core (LC), fibrous cap (FC), and intraplaque hemorrhage (IPH), and recording of the area percentage of LC and IPH, as well as the thickness of FC. Patients were categorized into stable plaque and vulnerable plaque groups based on diagnostic criteria for vulnerable plaques derived from imaging. Plaques were categorized based on meeting one of the following consensus criteria for vulnerability: lipid core area over 40% of total plaque area, fibrous cap thickness less than 65 um, or the presence of intraplaque hemorrhage. Plaques meeting the above criteria were designated as the LC-associated vulnerable plaque group, the IPH-associated group, and the FC-associated group. Multivariate logistic regression was employed to analyze the factors influencing carotid vulnerable plaques and specific vulnerable plaque components. Receiver operating characteristic (ROC) curves were used to assess the predictive value of serological indices for vulnerable carotid plaques.
UNASSIGNED: We found that THR (OR = 1.976; 95% CI = 1.094-3.570; p = 0.024) and TSH (OR = 1.939, 95% CI = 1.122-3.350, p = 0.018) contributed to the formation of vulnerable carotid plaques. THR exhibited an area under the curve (AUC) of 0.704 (95% CI = 0.588-0.803) (p = 0.003), and the AUC for TSH was 0.681 (95% CI = 0.564-0.783) (p = 0.008). THR was identified as an independent predictor of LC-associated vulnerable plaques (OR = 2.117, 95% CI = 1.064-4.212, p = 0.033), yielding an AUC of 0.815. THR also demonstrated diagnostic efficacy for LC-associated vulnerable plaques.
UNASSIGNED: This study substantiated that THR and TSH have predictive value for identifying vulnerable carotid plaques, with THR proving to be a more effective diagnostic indicator than TSH. THR also exhibited predictive value and specificity in the context of LC-associated vulnerable plaques. These findings suggest that THR may be a promising clinical indicator, outperforming TSH in detecting specific vulnerable carotid plaques.
UNASSIGNED: In this retrospective analysis, we included 76 patients with carotid plaques who met the criteria for admission to Zhejiang Hospital from July 2019 to June 2021. High-resolution magnetic resonance imaging (HRMRI) and the MRI-PlaqueView vascular plaque imaging diagnostic system were utilized to analyze carotid artery images for the identification of specific plaque components, including the lipid core (LC), fibrous cap (FC), and intraplaque hemorrhage (IPH), and recording of the area percentage of LC and IPH, as well as the thickness of FC. Patients were categorized into stable plaque and vulnerable plaque groups based on diagnostic criteria for vulnerable plaques derived from imaging. Plaques were categorized based on meeting one of the following consensus criteria for vulnerability: lipid core area over 40% of total plaque area, fibrous cap thickness less than 65 um, or the presence of intraplaque hemorrhage. Plaques meeting the above criteria were designated as the LC-associated vulnerable plaque group, the IPH-associated group, and the FC-associated group. Multivariate logistic regression was employed to analyze the factors influencing carotid vulnerable plaques and specific vulnerable plaque components. Receiver operating characteristic (ROC) curves were used to assess the predictive value of serological indices for vulnerable carotid plaques.
UNASSIGNED: We found that THR (OR = 1.976; 95% CI = 1.094-3.570; p = 0.024) and TSH (OR = 1.939, 95% CI = 1.122-3.350, p = 0.018) contributed to the formation of vulnerable carotid plaques. THR exhibited an area under the curve (AUC) of 0.704 (95% CI = 0.588-0.803) (p = 0.003), and the AUC for TSH was 0.681 (95% CI = 0.564-0.783) (p = 0.008). THR was identified as an independent predictor of LC-associated vulnerable plaques (OR = 2.117, 95% CI = 1.064-4.212, p = 0.033), yielding an AUC of 0.815. THR also demonstrated diagnostic efficacy for LC-associated vulnerable plaques.
UNASSIGNED: This study substantiated that THR and TSH have predictive value for identifying vulnerable carotid plaques, with THR proving to be a more effective diagnostic indicator than TSH. THR also exhibited predictive value and specificity in the context of LC-associated vulnerable plaques. These findings suggest that THR may be a promising clinical indicator, outperforming TSH in detecting specific vulnerable carotid plaques.
摘要：
■本研究旨在探讨促甲状腺激素与高密度脂蛋白胆固醇比率（THR）在识别特定易损颈动脉斑块中的预测价值。
■在此回顾性分析中，我们纳入了2019年7月至2021年6月浙江医院符合入院标准的颈动脉斑块患者76例.高分辨率磁共振成像（HRMRI）和MRI-PlaqueView血管斑块成像诊断系统用于分析颈动脉图像，以识别特定的斑块成分。包括脂质核心（LC），纤维帽(FC)，和斑块内出血（IPH），并记录LC和IPH的面积百分比，以及FC的厚度。根据影像学衍生的易损斑块的诊断标准，将患者分为稳定斑块和易损斑块组。根据满足以下易损性共识标准之一对斑块进行分类：脂质核心面积超过斑块总面积的40％，纤维帽厚度小于65微米，或斑块内出血的存在。符合上述标准的斑块被指定为LC相关易损斑块组，与IPH相关的组，和FC关联组。采用多因素logistic回归分析影响颈动脉易损斑块及特定易损斑块成分的因素。受试者工作特征（ROC）曲线用于评估血清学指标对颈动脉易损斑块的预测价值。
■我们发现THR(OR=1.976;95%CI=1.094-3.570;p=0.024)和TSH(OR=1.939,95%CI=1.122-3.350,p=0.018)有助于颈动脉易损斑块的形成。THR的曲线下面积（AUC）为0.704（95％CI=0.588-0.803）（p=0.003），TSH的AUC为0.681（95％CI=0.564-0.783）（p=0.008）。THR被确定为LC相关易损斑块的独立预测因子(OR=2.117,95%CI=1.064-4.212,p=0.033),产生0.815的AUC。THR还显示了对LC相关易损斑块的诊断功效。
■这项研究证实，THR和TSH对识别易损颈动脉斑块具有预测价值，THR被证明是比TSH更有效的诊断指标。THR在LC相关易损斑块的背景下也表现出预测价值和特异性。这些结果表明，THR可能是一个有前途的临床指标，在检测特定易损颈动脉斑块方面优于TSH。
■在此回顾性分析中，我们纳入了2019年7月至2021年6月浙江医院符合入院标准的颈动脉斑块患者76例.高分辨率磁共振成像（HRMRI）和MRI-PlaqueView血管斑块成像诊断系统用于分析颈动脉图像，以识别特定的斑块成分。包括脂质核心（LC），纤维帽(FC)，和斑块内出血（IPH），并记录LC和IPH的面积百分比，以及FC的厚度。根据影像学衍生的易损斑块的诊断标准，将患者分为稳定斑块和易损斑块组。根据满足以下易损性共识标准之一对斑块进行分类：脂质核心面积超过斑块总面积的40％，纤维帽厚度小于65微米，或斑块内出血的存在。符合上述标准的斑块被指定为LC相关易损斑块组，与IPH相关的组，和FC关联组。采用多因素logistic回归分析影响颈动脉易损斑块及特定易损斑块成分的因素。受试者工作特征（ROC）曲线用于评估血清学指标对颈动脉易损斑块的预测价值。
■我们发现THR(OR=1.976;95%CI=1.094-3.570;p=0.024)和TSH(OR=1.939,95%CI=1.122-3.350,p=0.018)有助于颈动脉易损斑块的形成。THR的曲线下面积（AUC）为0.704（95％CI=0.588-0.803）（p=0.003），TSH的AUC为0.681（95％CI=0.564-0.783）（p=0.008）。THR被确定为LC相关易损斑块的独立预测因子(OR=2.117,95%CI=1.064-4.212,p=0.033),产生0.815的AUC。THR还显示了对LC相关易损斑块的诊断功效。
■这项研究证实，THR和TSH对识别易损颈动脉斑块具有预测价值，THR被证明是比TSH更有效的诊断指标。THR在LC相关易损斑块的背景下也表现出预测价值和特异性。这些结果表明，THR可能是一个有前途的临床指标，在检测特定易损颈动脉斑块方面优于TSH。
