Abstract：
BACKGROUND: Prader-Willi syndrome (PWS) is commonly associated with intellectual disability, but also with a specific behavioural phenotype and a high predisposition to psychiatric comorbidity. This study examines the psychiatric care situation of people with PWS.
METHODS: A structured online questionnaire was administered to carers of people with PWS living in Germany, asking about demographic, diagnostic and treatment parameters as well as personal experiences.
RESULTS: Of 77 people with PWS, 44.2% had at least one psychiatric comorbid diagnosis. The main reasons for seeking psychiatric care were emotional outbursts and aggressive behaviour. 34.9% reported that they were currently seeking psychiatric care without success. However, 32.5% of PWS had been treated with psychotropic medication, mainly antipsychotics.
CONCLUSIONS: Psychiatric comorbidity appears to be undertreated in PWS, especially in the ambulatory setting. Uncertainty among mental health care providers may also lead to frequent off-label use of psychotropic medications.
METHODS: A structured online questionnaire was administered to carers of people with PWS living in Germany, asking about demographic, diagnostic and treatment parameters as well as personal experiences.
RESULTS: Of 77 people with PWS, 44.2% had at least one psychiatric comorbid diagnosis. The main reasons for seeking psychiatric care were emotional outbursts and aggressive behaviour. 34.9% reported that they were currently seeking psychiatric care without success. However, 32.5% of PWS had been treated with psychotropic medication, mainly antipsychotics.
CONCLUSIONS: Psychiatric comorbidity appears to be undertreated in PWS, especially in the ambulatory setting. Uncertainty among mental health care providers may also lead to frequent off-label use of psychotropic medications.
摘要：
背景：Prader-Willi综合征（PWS）通常与智力障碍有关，而且具有特定的行为表型和对精神病合并症的高易感性。这项研究检查了PWS患者的精神护理状况。
方法：对居住在德国的PWS患者的照顾者进行了结构化的在线问卷调查，询问人口统计，诊断和治疗参数以及个人经验。
结果：77名PWS患者中，44.2%有至少一种精神病共病诊断。寻求精神病治疗的主要原因是情绪爆发和攻击行为。34.9%的人报告说他们目前正在寻求精神病治疗，但没有成功。然而,32.5%的PWS曾接受精神药物治疗,主要是抗精神病药。
结论：PWS的精神病合并症治疗不足，尤其是在非卧床环境中。精神卫生保健提供者之间的不确定性也可能导致频繁的超标签使用精神药物。
方法：对居住在德国的PWS患者的照顾者进行了结构化的在线问卷调查，询问人口统计，诊断和治疗参数以及个人经验。
结果：77名PWS患者中，44.2%有至少一种精神病共病诊断。寻求精神病治疗的主要原因是情绪爆发和攻击行为。34.9%的人报告说他们目前正在寻求精神病治疗，但没有成功。然而,32.5%的PWS曾接受精神药物治疗,主要是抗精神病药。
结论：PWS的精神病合并症治疗不足，尤其是在非卧床环境中。精神卫生保健提供者之间的不确定性也可能导致频繁的超标签使用精神药物。
