PDF(Pubmed)
Abstract：
The microbiome plays a critical role in the process of conception and the outcomes of pregnancy. Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications, which significantly impact maternal and fetal health. Recent studies have associated the microbiome in the female reproductive tract (FRT) with assisted reproductive technology (ART) outcomes, and restoring microbiome balance has been shown to improve fertility in infertile couples. This review provides an overview of the role of the microbiome in female reproductive health, including its implications for pregnancy outcomes and ARTs. Additionally, recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized. A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal health. Such knowledge can also contribute to the development of ARTs and microbiome-based interventions.
摘要：
微生物组在受孕过程和妊娠结局中起着至关重要的作用。生育年龄妇女微生物组稳态的破坏可导致各种妊娠并发症，这对母亲和胎儿的健康有很大的影响。最近的研究已经将女性生殖道（FRT）中的微生物组与辅助生殖技术（ART）结果相关联。恢复微生物组平衡已被证明可以改善不育夫妇的生育能力。这篇综述概述了微生物组在女性生殖健康中的作用。包括其对妊娠结局和ARTs的影响。此外,总结了微生物生物标志物作为妊娠疾病指标的最新进展。全面了解孕前和孕期微生物组的特点及其对生殖健康的影响，将极大地促进孕产妇和胎儿的健康。这些知识也可以促进基于抗逆转录病毒疗法和微生物组的干预措施的发展。
