Abstract：
BACKGROUND: The stage of life at the onset of obesity is an important factor in assessing inflammatory state and cardiometabolic risk.
OBJECTIVE: This study aimed to evaluate the relationship between the obesity onset and the inflammatory profile in women with severe obesity.
METHODS: Public hospital, Brazil.
METHODS: Forty-eight women with severe obesity (20-59 yr old) were evaluated according to weight, height, neck circumference (NC), waist circumference (WC), and hip circumference, as well blood metabolic and inflammatory parameters. The participants were grouped according to obesity onset stage of life (early group: ≤19 yr; late group: >19 yr).
RESULTS: The demographic means of the participants were: age of 39.7 years, weight of 122.7 kg and body mass index (BMI) of 48.4 kg/m2. The late group presented significantly higher values of leptin (lep)/adiponectin (adipo) ratio and homeostatic model assessment for insulin resistance (HOMA-IR) than the early group. The late group also had a lower adipo/lep ratio. Moreover, the late group showed correlations between the lep/adipo ratio and BMI (r = .460, P = .021), NC (r = .478, P = .016), and WC (r = .535, P = .006). Adipo was also correlated with NC (r = -.418, P = .038), WC (r = -.437, P = .029), and glycated hemoglobin (HbA1C) (r = -.485, P = .019). By contrast, in the early group, the lep/adipo ratio showed correlations with insulin (r = .647, P = .004) and HOMA-B (r = .564, P = .015).
CONCLUSIONS: The inflammatory profile is correlated with anthropometric values in women with late-onset obesity. Inflammatory markers seemed to correlate with the glycemic profile in women with early-onset obesity. Furthermore, inflammation was higher in women with late-onset obesity compared to those with early-onset obesity.
OBJECTIVE: This study aimed to evaluate the relationship between the obesity onset and the inflammatory profile in women with severe obesity.
METHODS: Public hospital, Brazil.
METHODS: Forty-eight women with severe obesity (20-59 yr old) were evaluated according to weight, height, neck circumference (NC), waist circumference (WC), and hip circumference, as well blood metabolic and inflammatory parameters. The participants were grouped according to obesity onset stage of life (early group: ≤19 yr; late group: >19 yr).
RESULTS: The demographic means of the participants were: age of 39.7 years, weight of 122.7 kg and body mass index (BMI) of 48.4 kg/m2. The late group presented significantly higher values of leptin (lep)/adiponectin (adipo) ratio and homeostatic model assessment for insulin resistance (HOMA-IR) than the early group. The late group also had a lower adipo/lep ratio. Moreover, the late group showed correlations between the lep/adipo ratio and BMI (r = .460, P = .021), NC (r = .478, P = .016), and WC (r = .535, P = .006). Adipo was also correlated with NC (r = -.418, P = .038), WC (r = -.437, P = .029), and glycated hemoglobin (HbA1C) (r = -.485, P = .019). By contrast, in the early group, the lep/adipo ratio showed correlations with insulin (r = .647, P = .004) and HOMA-B (r = .564, P = .015).
CONCLUSIONS: The inflammatory profile is correlated with anthropometric values in women with late-onset obesity. Inflammatory markers seemed to correlate with the glycemic profile in women with early-onset obesity. Furthermore, inflammation was higher in women with late-onset obesity compared to those with early-onset obesity.
摘要：
背景：肥胖发作时的生命阶段是评估炎症状态和心脏代谢风险的重要因素。
目的：本研究旨在评估重度肥胖女性肥胖发病与炎症特征之间的关系。
方法：公立医院，巴西。
方法：根据体重对48名重度肥胖妇女（20-59岁）进行评估，高度,颈围（NC），腰围（WC），和臀围，以及血液代谢和炎症参数。根据肥胖发作阶段对参与者进行分组（早期组：≤19岁；晚期组：>19岁）。
结果：参与者的人口统计学方法为：年龄39.7岁，体重为122.7kg，体重指数（BMI）为48.4kg/m2。晚期组的瘦素（lep）/脂联素（adipo）比值和胰岛素抵抗的稳态模型评估（HOMA-IR）明显高于早期组。晚期组的adipo/lep比率也较低。此外，晚期组显示lep/adipo比率与BMI之间存在相关性（r=.460，P=.021），NC（r=.478，P=.016），和WC（r=.535，P=.006）。Adipo也与NC相关(r=-.418，P=.038)，WC（r=-.437，P=.029），糖化血红蛋白（HbA1C）（r=-.485，P=.019）。相比之下,在早期群体中，lep/adipo比值与胰岛素（r=.647，P=.004）和HOMA-B（r=.564，P=.015）相关。
结论：晚发性肥胖女性的炎症谱与人体测量值相关。炎症标志物似乎与早发性肥胖女性的血糖状况相关。此外，迟发性肥胖女性的炎症反应高于早发性肥胖女性.
目的：本研究旨在评估重度肥胖女性肥胖发病与炎症特征之间的关系。
方法：公立医院，巴西。
方法：根据体重对48名重度肥胖妇女（20-59岁）进行评估，高度,颈围（NC），腰围（WC），和臀围，以及血液代谢和炎症参数。根据肥胖发作阶段对参与者进行分组（早期组：≤19岁；晚期组：>19岁）。
结果：参与者的人口统计学方法为：年龄39.7岁，体重为122.7kg，体重指数（BMI）为48.4kg/m2。晚期组的瘦素（lep）/脂联素（adipo）比值和胰岛素抵抗的稳态模型评估（HOMA-IR）明显高于早期组。晚期组的adipo/lep比率也较低。此外，晚期组显示lep/adipo比率与BMI之间存在相关性（r=.460，P=.021），NC（r=.478，P=.016），和WC（r=.535，P=.006）。Adipo也与NC相关(r=-.418，P=.038)，WC（r=-.437，P=.029），糖化血红蛋白（HbA1C）（r=-.485，P=.019）。相比之下,在早期群体中，lep/adipo比值与胰岛素（r=.647，P=.004）和HOMA-B（r=.564，P=.015）相关。
结论：晚发性肥胖女性的炎症谱与人体测量值相关。炎症标志物似乎与早发性肥胖女性的血糖状况相关。此外，迟发性肥胖女性的炎症反应高于早发性肥胖女性.
