METHODS: Adult patients from an observational radiotherapy study for painful bone metastases self-reported NIS and WL using the Patient-Generated Subjective Global Assessment tool (PG-SGA) at baseline and week eight (W8). NIS burden, the sum of NIS per patient, categorised as 0, 1-2 and ≥3 with changes defined as 2-point differences from baseline to W8 were used. Energy intake was assessed by 24-hour recall interviews.
RESULTS: 111 patients (72.1%) were analysed and grouped by NIS burden; 0 NIS (44.1%), 1-2 NIS (30.6%) and ≥3 NIS (25.2%). Patients with NIS burden of ≥3 reported higher baseline WL compared with those with 1-2 or 0 NIS (46.4% vs 18.2% vs 10.2%, respectively, p=0.002). At W8, 21 patients (19%) reported improved NIS burden, accompanied by a lower proportion of severe (≥5%) new-onset WL (19% vs 42.1%) and higher energy intake (median 29.6 vs 21.2 kcal/kg) than those with worsened NIS burden (17.1%).
CONCLUSIONS: NIS management may improve energy intake and prevent WL, emphasising the importance of systematic follow-up and interventions.
UNASSIGNED: NCT02107664.
方法:在基线和第8周(W8)使用患者生成的主观整体评估工具(PG-SGA),对疼痛性骨转移进行观察性放疗研究的成年患者自我报告NIS和WL。NIS负担,每位患者的NIS总和,使用分类为0,1-2和≥3的变化定义为从基线到W8的2点差异.通过24小时召回访谈评估能量摄入。
结果:111例患者(72.1%)进行了分析,并按NIS负荷进行了分组;0NIS(44.1%),1-2NIS(30.6%)和≥3NIS(25.2%)。NIS负荷≥3的患者报告的基线WL高于NIS1-2或0的患者(46.4%vs18.2%vs10.2%,分别,p=0.002)。在W8,21名患者(19%)报告NIS负担改善,与NIS负担恶化的患者(17.1%)相比,严重(≥5%)新发WL的比例(19%vs42.1%)和较高的能量摄入(中位数29.6vs21.2kcal/kg)。
结论:NIS管理可以改善能量摄入并预防WL,强调有系统的后续行动和干预措施的重要性。
■NCT02107664。