{Reference Type}: Journal Article
{Title}: Nutrition impact symptom monitoring and weight loss outcomes: a longitudinal radiotherapy study.
{Author}: Urrizola A;Dajani O;Aass N;Bjerkeset E;Hjermstad MJ;Kaasa S;Klepstad P;Pirnat A;Raaness I;Steinsheim H;Bye A;
{Journal}: BMJ Support Palliat Care
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 11
{Factor}: 4.633
{DOI}: 10.1136/spcare-2024-004939
{Abstract}: <B>OBJECTIVE: </B>Nutrition impact symptoms (NIS) are associated with weight loss (WL), and decreased energy intake in cross-sectional studies. We aimed to ascertain associations between changes in NIS burden, energy intake and WL over time in patients with advanced cancer.<BR><B>METHODS: </B>Adult patients from an observational radiotherapy study for painful bone metastases self-reported NIS and WL using the Patient-Generated Subjective Global Assessment tool (PG-SGA) at baseline and week eight (W8). NIS burden, the sum of NIS per patient, categorised as 0, 1-2 and ≥3 with changes defined as 2-point differences from baseline to W8 were used. Energy intake was assessed by 24-hour recall interviews.<BR><B>RESULTS: </B>111 patients (72.1%) were analysed and grouped by NIS burden; 0 NIS (44.1%), 1-2 NIS (30.6%) and ≥3 NIS (25.2%). Patients with NIS burden of ≥3 reported higher baseline WL compared with those with 1-2 or 0 NIS (46.4% vs 18.2% vs 10.2%, respectively, p=0.002). At W8, 21 patients (19%) reported improved NIS burden, accompanied by a lower proportion of severe (≥5%) new-onset WL (19% vs 42.1%) and higher energy intake (median 29.6 vs 21.2 kcal/kg) than those with worsened NIS burden (17.1%).<BR><B>CONCLUSIONS: </B>NIS management may improve energy intake and prevent WL, emphasising the importance of systematic follow-up and interventions.<BR><B>UNASSIGNED: </B>NCT02107664.