Abstract：
Hidradenitis suppurativa (HS) is a chronic, debilitating skin condition that requires multimodal treatment. Adherence remains a significant challenge for many patients due to complex nature of treatment, thus presenting a barrier to management success. This review summarizes the current literature on the factors associated with adherence to medications, and lifestyle behaviors in patients with HS and proposes strategies to improve adherence. In February 2023, a systematic literature search was conducted by two independent authors on PubMed and EMBASE for articles from 2000 to 2023 on hidradenitis suppurativa adherence. A total of 21 articles met inclusion/exclusion criteria for this review. Of the studies, 11 addressed systemic medication adherence, 3 addressed topical medication adherence, 2 addressed both systemic and topical medication adherence, and 5 addressed lifestyle/behavioral modification adherence. The generalizability of results was limited by differences in study design, outcome measures, and sample size. English-only articles with full texts were used. The most reported reasons for non-adherence included presence of side effects, cost of medications, low efficacy, and unclear instructions. Proposed strategies to improve adherence in HS patients include management of side effects, use of reminder systems, improved patient education, patient support groups, aid of family and caregivers, personalization of the medication regimen, and regular follow-ups with patients. PROSPERO Registration Number: CRD42023488549.
摘要：
化脓性汗腺炎（HS）是一种慢性，需要多模式治疗的衰弱皮肤状况。由于治疗的复杂性，坚持对许多患者来说仍然是一个重大挑战。从而给管理成功带来障碍。这篇综述总结了与药物依从性相关的因素，和HS患者的生活方式行为，并提出了提高依从性的策略。2023年2月，由PubMed和EMBASE的两名独立作者进行了系统的文献检索，以获取2000年至2023年关于化脓性汗腺炎依从性的文章。共有21篇文章符合本综述的纳入/排除标准。在研究中，11解决了全身药物依从性，3解决了局部用药依从性，2解决了全身和局部用药依从性，5涉及生活方式/行为矫正依从性。结果的普遍性受到研究设计差异的限制，结果衡量标准，和样本量。只使用英文的文章和全文。报道最多的不依从性原因包括存在副作用，药费,低功效,和不清楚的指示。改善HS患者依从性的建议策略包括副作用的管理，使用提醒系统，改善患者教育，患者支持团体,家庭和照顾者的援助，药物治疗方案的个性化，并定期对患者进行随访。PROSPERO注册号：CRD42023488549。
