Abstract：
The relevance of the problem of immunoinflammatory rheumatic diseases (IIRD) for modern medicine is determined by their high prevalence in the population, the difficulty of early diagnosis, the rapid development of disability and poor life prognosis. Recent data on the significance of anti-DFS70 have opened up new possibilities for optimizing the step-by-step diagnosis of IIRD. The detection of these antibodies can help in the interpretation of a positive result for antinuclear antibodies (ANA) by indirect immunofluorescence assay on HEp-2 cells (IIFA-HEp-2) in the absence of autoantibodies specific for IIRD. Detection of anti-DFS70 in antinuclear factor (ANF) seropositive patients without clinical and/or serological markers characteristic of a certain disease from the IIRD group can be considered as a potential marker that excludes this group of diseases.
摘要：
免疫炎性风湿性疾病（IIRD）与现代医学的相关性取决于其在人群中的高患病率，早期诊断的困难，残疾发展迅速,生活预后差。有关抗DFS70重要性的最新数据为优化IIRD的逐步诊断开辟了新的可能性。在不存在IIRD特异性自身抗体的情况下，通过对HEp-2细胞（IIFA-HEp-2）的间接免疫荧光测定，这些抗体的检测可以帮助解释抗核抗体（ANA）的阳性结果。在不具有来自IIRD组的某种疾病的临床和/或血清学标志物特征的抗核因子(ANF)血清阳性患者中检测抗DFS70可以被认为是排除该组疾病的潜在标志物。
