Abstract：
Organophosphorus (OP) poisoning is a significant cause of morbidity and mortality worldwide. Recent research has explored new approaches to improving treatment options, which present several challenges. This study aimed to evaluate the role of fresh frozen plasma (FFP) as an adjunctive therapy for acute OP intoxication. A prospective single-blinded randomized clinical trial was conducted on patients of both sexes admitted to the Intensive Care Unit (ICU) of the Poison Control Center at Ain Shams University Hospital (PCC-ASUH) with acute OP toxicity during the period from the beginning of August 2022 to the end of July 2023. According to the Peradeniya score, Group I consisted of 48 patients (52%) with moderate OP poisoning, and Group II consisted of 44 patients (48%) with severe OP poisoning. Patients in the moderate group were assigned to receive either standard treatment (Group Ia, n = 24) or standard treatment plus FFP (Group Ib, n = 24). In addition, patients in the severe group were assigned to receive either standard treatment (Group IIa, n = 22) or standard treatment plus FFP (Group IIb, n = 22). A total of 46 patients received FFP transfusion. The authors demonstrated that the early use of a total of nine packs of FFP (250 mL each) over three consecutive days significantly reduced the total doses of atropine and oximes, the total hospitalization period, and the requirement for mechanical ventilation in patients with OP poisoning, both in the moderate and severe groups.
摘要：
有机磷（OP）中毒是世界范围内发病率和死亡率的重要原因。最近的研究探索了改善治疗方案的新方法，这带来了一些挑战。本研究旨在评估新鲜冰冻血浆（FFP）作为急性OP中毒辅助治疗的作用。对AinShams大学医院（PCC-ASUH）毒物控制中心重症监护病房（ICU）收治的男女患者进行了一项前瞻性单盲随机临床试验，该期间患有急性OP毒性2022年8月至2023年7月底。根据Peradeniya的评分,第一组由48例（52%）中度OP中毒患者组成，而II组包括44例(48%)重度OP中毒患者.中度组的患者被分配接受任一标准治疗(Ia组，n=24)或标准治疗加FFP(Ib组，n=24）。此外,严重组的患者被分配接受两种标准治疗(IIa组，n=22)或标准治疗加FFP(IIb组，n=22）。共有46例患者接受FFP输血。作者证明，在连续三天内早期使用总共9包FFP（每包250mL）显着降低了阿托品和肟的总剂量，总住院期间，以及OP中毒患者对机械通气的要求，在中度和重度组中。
