Abstract：
Kaposi sarcoma (KS) is a low-grade vascular neoplasm that can be seen in various sites, most commonly seen in skin and mucosal tissues. Cytologic features of KS have been well-documented in the literature, however, since it is rarely seen in visceral organs, it could pose significant diagnostic challenges on fine needle aspiration (FNA) biopsies. We present a case of pulmonary KS diagnosed on transbronchial FNA biopsy in a 70-year-old female bilateral lung allograft recipient 11 months after transplantation. The aspirate smears showed a moderately cellular specimen containing a mixture of small, tightly cohesive clusters and loosely clustered groups of monomorphic, ovoid to spindled cells with moderate nuclear to cytoplasmic ratio. An extensive immunohistochemical panel on the concurrent core biopsy showed the tumor cells to be positive for ERG, KIT, and HHV8, confirming the diagnosis. We compared our case to previously published reports of confirmed pulmonary KS in lung allograft recipients.
摘要：
卡波西肉瘤（KS）是一种可以在不同部位看到的低度血管肿瘤，最常见于皮肤和粘膜组织。KS的细胞学特征已经在文献中得到了充分的记录，然而,因为它在内脏器官中很少见，它可能对细针穿刺活检(FNA)造成重大的诊断挑战.我们介绍了一名70岁的女性双侧同种异体肺移植后11个月，在经支气管FNA活检中诊断为肺KS的病例。抽吸涂片显示一个中等细胞的标本，含有小的混合物，紧密凝聚的团簇和松散聚集的单态群，卵形至纺锤形细胞，核质比例适中。同时进行的核心活检的广泛的免疫组织化学面板显示肿瘤细胞对ERG呈阳性，KIT,和HHV8，确认诊断。我们将我们的病例与先前发表的关于同种异体肺移植受者中确认的肺KS的报道进行了比较。
