PDF(Pubmed)
Abstract：
Microscopic colitis (MC) is characterized by chronic watery diarrhea that requires histological examination for diagnosis. Here, we present a case of a 63-year-old female with rheumatoid arthritis who developed persistent diarrhea following leflunomide initiation. Despite a normal colonoscopy, random colonic biopsies confirmed MC. Discontinuation of leflunomide led to symptom resolution, implicating it as the causative agent. Leflunomide-induced MC is exceedingly rare, with limited documented cases. Understanding its variability in presentation and timely recognition is crucial. This case underscores the importance of thorough medication history assessment and consideration of drug-induced colitis in patients presenting with unexplained diarrhea, facilitating prompt management and resolution.
摘要：
显微镜结肠炎（MC）的特征是慢性水样腹泻，需要进行组织学检查才能诊断。这里,我们介绍了一例63岁的类风湿关节炎女性患者,在开始使用来氟米特后出现持续性腹泻.尽管结肠镜检查正常，随机结肠活检证实MC。停用来氟米特导致症状缓解，暗示它是致病因素。来氟米特诱导的MC非常罕见，有限的记录在案的案件。了解其在演示和及时识别中的可变性至关重要。该病例强调了对不明原因腹泻患者进行全面用药史评估和考虑药物性结肠炎的重要性。促进及时的管理和解决。
