Abstract：
BACKGROUND: In people with intellectual disabilities and/or autism spectrum disorder, oral midazolam (OM) is very effective as premedication for facilitating medical treatment. In this retrospective study, we investigated the optimal dosage of OM for premedication.
METHODS: Patients with intellectual disability and/or autism spectrum disorder who were given OM as a premedication were selected from anaesthesia records. The primary outcome variable was the dose of OM (mg/kg) required to produce an adequate sedation.
RESULTS: The mean OM dose required was 0.32 ± 0.10 mg/kg. The required OM dose decreased significantly as age and weight increased, and age and weight were also shown to be significantly associated with the dose of OM in the multivariate linear regression analysis.
CONCLUSIONS: The dosage of OM to achieve adequate sedation should decrease as the patient ages. Furthermore, adequate sedation can be achieved with even lower doses of OM in obese people.
METHODS: Patients with intellectual disability and/or autism spectrum disorder who were given OM as a premedication were selected from anaesthesia records. The primary outcome variable was the dose of OM (mg/kg) required to produce an adequate sedation.
RESULTS: The mean OM dose required was 0.32 ± 0.10 mg/kg. The required OM dose decreased significantly as age and weight increased, and age and weight were also shown to be significantly associated with the dose of OM in the multivariate linear regression analysis.
CONCLUSIONS: The dosage of OM to achieve adequate sedation should decrease as the patient ages. Furthermore, adequate sedation can be achieved with even lower doses of OM in obese people.
摘要：
背景：在患有智力障碍和/或自闭症谱系障碍的人中，口服咪达唑仑（OM）作为促进药物治疗的前药非常有效。在这项回顾性研究中,我们研究了前用药的最佳OM剂量。
方法：从麻醉记录中选择患有智力障碍和/或自闭症谱系障碍的患者，并在术前给予OM。主要结果变量是产生足够镇静所需的OM剂量（mg/kg）。
结果：所需的平均OM剂量为0.32±0.10mg/kg。随着年龄和体重的增加，所需的OM剂量显着降低，在多元线性回归分析中,年龄和体重也显示与OM剂量显著相关.
结论：实现足够镇静的OM剂量应随着患者年龄的增长而减少。此外，在肥胖者中,使用更低剂量的OM可以达到足够的镇静作用.
方法：从麻醉记录中选择患有智力障碍和/或自闭症谱系障碍的患者，并在术前给予OM。主要结果变量是产生足够镇静所需的OM剂量（mg/kg）。
结果：所需的平均OM剂量为0.32±0.10mg/kg。随着年龄和体重的增加，所需的OM剂量显着降低，在多元线性回归分析中,年龄和体重也显示与OM剂量显著相关.
结论：实现足够镇静的OM剂量应随着患者年龄的增长而减少。此外，在肥胖者中,使用更低剂量的OM可以达到足够的镇静作用.
