PDF(Pubmed)
Abstract：
BACKGROUND: This study aimed to investigate the alterations in structural integrity of superior longitudinal fasciculus subcomponents with increasing white matter hyperintensity severity as well as the relationship to cognitive performance in cerebral small vessel disease.
METHODS: 110 cerebral small vessel disease study participants with white matter hyperintensities were recruited. According to Fazekas grade scale, white matter hyperintensities of each subject were graded. All subjects were divided into two groups. The probabilistic fiber tracking method was used for analyzing microstructure characteristics of superior longitudinal fasciculus subcomponents.
RESULTS: Probabilistic fiber tracking results showed that mean diffusion, radial diffusion, and axial diffusion values of the left arcuate fasciculus as well as the mean diffusion value of the right arcuate fasciculus and left superior longitudinal fasciculus III in high white matter hyperintensities rating group were significantly higher than those in low white matter hyperintensities rating group (p < 0.05). The mean diffusion value of the left superior longitudinal fasciculus III was negatively related to the Montreal Cognitive Assessment score of study participants (p < 0.05).
CONCLUSIONS: The structural integrity injury of bilateral arcuate fasciculus and left superior longitudinal fasciculus III is more severe with the aggravation of white matter hyperintensities. The structural integrity injury of the left superior longitudinal fasciculus III correlates to cognitive impairment in cerebral small vessel disease.
METHODS: 110 cerebral small vessel disease study participants with white matter hyperintensities were recruited. According to Fazekas grade scale, white matter hyperintensities of each subject were graded. All subjects were divided into two groups. The probabilistic fiber tracking method was used for analyzing microstructure characteristics of superior longitudinal fasciculus subcomponents.
RESULTS: Probabilistic fiber tracking results showed that mean diffusion, radial diffusion, and axial diffusion values of the left arcuate fasciculus as well as the mean diffusion value of the right arcuate fasciculus and left superior longitudinal fasciculus III in high white matter hyperintensities rating group were significantly higher than those in low white matter hyperintensities rating group (p < 0.05). The mean diffusion value of the left superior longitudinal fasciculus III was negatively related to the Montreal Cognitive Assessment score of study participants (p < 0.05).
CONCLUSIONS: The structural integrity injury of bilateral arcuate fasciculus and left superior longitudinal fasciculus III is more severe with the aggravation of white matter hyperintensities. The structural integrity injury of the left superior longitudinal fasciculus III correlates to cognitive impairment in cerebral small vessel disease.
摘要：
背景：本研究旨在探讨脑小血管疾病中上纵行筋膜亚组件结构完整性随白质高强度严重程度增加的变化以及与认知功能的关系。
方法：招募了110名脑小血管病白质高信号研究参与者。根据法泽卡斯等级表,对每位受试者的白质高信号进行分级.将所有受试者分为两组。采用概率纤维跟踪方法分析了上纵束子组件的微观结构特征。
结果：概率纤维跟踪结果表明，平均扩散，径向扩散，高白质高强度评级组的左弓形束的轴向扩散值以及右弓形束和左上纵向束III的平均扩散值显着高于低白质高强度评级组（p<0.05）。左上纵束III的平均扩散值与研究参与者的蒙特利尔认知评估评分呈负相关(p<0.05)。
结论：双侧弓状束和左侧上纵束III的结构完整性损伤随着白质高信号的加重而加重。左上纵束III的结构完整性损伤与脑小血管病的认知障碍相关。
方法：招募了110名脑小血管病白质高信号研究参与者。根据法泽卡斯等级表,对每位受试者的白质高信号进行分级.将所有受试者分为两组。采用概率纤维跟踪方法分析了上纵束子组件的微观结构特征。
结果：概率纤维跟踪结果表明，平均扩散，径向扩散，高白质高强度评级组的左弓形束的轴向扩散值以及右弓形束和左上纵向束III的平均扩散值显着高于低白质高强度评级组（p<0.05）。左上纵束III的平均扩散值与研究参与者的蒙特利尔认知评估评分呈负相关(p<0.05)。
结论：双侧弓状束和左侧上纵束III的结构完整性损伤随着白质高信号的加重而加重。左上纵束III的结构完整性损伤与脑小血管病的认知障碍相关。
