Abstract：
The resolution of inflammation, the other side of the inflammatory response, is defined as an active and highly coordinated process that promotes the restoration of immune microenvironment balance and tissue repair. Inflammation resolution involves several key processes, including dampening proinflammatory signaling, specialized proresolving lipid mediator (SPM) production, nonlipid proresolving mediator production, efferocytosis and regulatory T-cell (Treg) induction. In recent years, increasing attention has been given to the effects of inflammation resolution on hypertension. Furthermore, our previous studies reported the antihypertensive effects of SPMs. Therefore, in this review, we aim to summarize and discuss the detailed association between arterial hypertension and inflammation resolution. Additional, the association between gut microbe-mediated immune and hypertension is discussed. This findings suggested that accelerating the resolution of inflammation can have beneficial effects on hypertension and its related organ damage. Exploring novel drug targets by focusing on various pathways involved in accelerating inflammation resolution will contribute to the treatment and control of hypertensive diseases in the future.
摘要：
炎症的解决，炎症反应的另一面，被定义为一个积极的和高度协调的过程，促进免疫微环境平衡和组织修复的恢复。炎症消退涉及几个关键过程，包括抑制促炎信号，专门的分解脂质介体(SPM)生产，非脂质分解介体生产，细胞外化和调节性T细胞（Treg）诱导。近年来,炎症消退对高血压的影响日益受到重视。此外，我们以前的研究报道了SPM的抗高血压作用。因此，在这次审查中,我们旨在总结和讨论动脉高血压与炎症消退之间的详细关联。额外,讨论了肠道微生物介导的免疫与高血压之间的关联。这一发现表明，加速炎症的消退可以对高血压及其相关器官损伤产生有益的影响。通过关注加速炎症消退的各种途径来探索新的药物靶标将有助于未来高血压疾病的治疗和控制。
