Abstract：
Falls pose a significant threat to older adults, resulting in injuries and mortality. Concurrently prescribed opioids and gabapentin for pain management may increase fall risks in older patients. This study aimed to estimate fall risks associated with the concurrent use of gabapentin and opioids, comparing them to opioid monotherapy in older adults. A retrospective case-control study of 1,813 patients aged 65-89 on chronic opioid therapy (2017-2020), excluding those with a fall history, analysis focused on the first fall occurrence. Logistic regression assessed the association between concurrent gabapentin and opioid use and fall events. Out of eligible patients, 122 (6.73%) experienced falls during opioid therapy, with 232 (12.80%) having concurrent gabapentin use. Concurrent use significantly increased fall risk (AOR = 1.73; 95% CI: 1.08-2.78). Being female, aged ≥81, and having more chronic conditions also increased risk. Mitigating fall risk in older adults requires education on prevention, exploring alternative pain management, and careful consideration of prescribing. Further research is crucial to understand adverse events linked to combined opioid and gabapentin use in the geriatric population.
摘要：
跌倒对老年人构成重大威胁，造成伤害和死亡。同时处方阿片类药物和加巴喷丁用于疼痛管理可能会增加老年患者的跌倒风险。这项研究旨在评估与同时使用加巴喷丁和阿片类药物相关的跌倒风险。将它们与老年人的阿片类药物单一疗法进行比较。1,813例65-89岁慢性阿片类药物治疗患者（2017-2020年）的回顾性病例对照研究，不包括那些有堕落历史的人，分析的重点是第一次跌倒。Logistic回归分析了加巴喷丁与阿片类药物使用和跌倒事件的相关性。在符合条件的患者中，122（6.73％）在阿片类药物治疗期间跌倒，232（12.80%）同时使用加巴喷丁。同时使用显著增加跌倒风险(AOR=1.73;95%CI:1.08-2.78)。作为女性，年龄≥81岁，患有更多慢性疾病也会增加风险。减轻老年人的跌倒风险需要进行预防教育，探索替代疼痛管理，并仔细考虑开处方。进一步的研究对于了解老年人群中与阿片类药物和加巴喷丁联合使用相关的不良事件至关重要。
