关键词: Cardiovascular disease Coil embolization Computational fluid dynamics Hemodynamics Intracranial aneurysm

来  源:   DOI:10.1007/s11517-024-03146-4

Abstract:
Aneurysms are bulges of an artery, which require clinical management solutions. Due to the inherent advantages, endovascular coil filling is emerging as the treatment of choice for intracranial aneurysms (IAs). However, after successful treatment of coil embolization, there is a serious risk of recurrence. It is well known that optimal packing density will enhance treatment outcomes. The main objective of endovascular coil embolization is to achieve flow stasis by enabling significant reduction in intra-aneurysmal flow and facilitate thrombus formation. The present study numerically investigates the effect of framing coil orientation on intra-aneurysmal hemodynamics. For the purpose of analysis, actual shape of the embolic coil is used, instead of simplified ideal coil shape. Typically used details of the framing coil are resolved for the analysis. However, region above the framing coil is assumed to be filled with a porous medium. Present simulations have shown that orientation of the framing coil loop (FCL) greatly influences the intra-aneurysmal hemodynamics. The FCLs which were placed parallel to the outlets of basilar tip aneurysm (Coil A) were found to reduce intra-aneurysmal flow velocity that facilitates thrombus formation. Involving the coil for the region is modeled using a porous medium model with a packing density of 20 % . The simulations indicate that the framing coil loop (FCL) has a significant influence on the overall outcome.
摘要:
动脉瘤是动脉的隆起,这需要临床管理解决方案。由于固有的优势,血管内线圈填充正在成为颅内动脉瘤(IAs)的首选治疗方法。然而,成功治疗线圈栓塞后,有严重的复发风险。众所周知,最佳堆积密度将增强治疗结果。血管内弹簧圈栓塞的主要目的是通过显着减少动脉瘤内血流并促进血栓形成来实现血流停滞。本研究通过数值研究了框架线圈方向对动脉瘤内血流动力学的影响。为了分析的目的,使用栓塞线圈的实际形状,而不是简化的理想线圈形状。通常使用的框架线圈的细节被解析用于分析。然而,假定框架线圈上方的区域填充有多孔介质。目前的模拟表明,框架线圈环(FCL)的方向极大地影响了动脉瘤内的血液动力学。发现平行于基底尖端动脉瘤(线圈A)出口放置的FCL可降低动脉瘤内流速,从而促进血栓形成。使用堆积密度为20%的多孔介质模型对涉及该区域的线圈进行建模。模拟表明,成帧线圈回路(FCL)对总体结果具有显著影响。
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