Abstract：
OBJECTIVE: Arteriovenous fistula (AVF) structures are vital formations used for hemodialysis. Diabetes mellitus (DM) is a critical disease affecting the vascular system. The triglyceride glucose (TyG) index has been shown to be associated with major adverse cardiovascular events in patients with Type 2 DM. In this study, we aimed to investigate the effect of the TyG index on the primary AVF patency of diabetic patients.
METHODS: Between March 2018 and March 2023, patients with DM who underwent AVF surgery in our clinic due to end-stage renal disease were retrospectively included in this study. The patients who could receive hemodialysis were determined as Group 1, and those who could not were determined as Group 2.
RESULTS: A total of 189 patients were included in the study. Those who did not develop AVF primary failure were included in Group 1 [n=138, median age = 59 (22-77) years], and those who did were included in Group 2 [n=51, median age = 63 (20-81) years]. In the multivariate analysis, age >70 years (OR: 0.871, 95% CI: 0.594-0.983, p=0.039), the presence of PAD (OR: 0.582, 95% CI: 0.0.458-0.896, p=0.046), and TyG index (OR: 0.879, 95% CI: 0.591-0.916, p<0.001) were determined as independent predictors for primary AVF failure.
CONCLUSIONS: This study demonstrated that the TyG index value, calculated from blood samples taken at the time of hospital admission in hemodialysis patients with diabetes mellitus (DM), is an independent predictor of primary AVF failure following AVF surgery.
METHODS: Between March 2018 and March 2023, patients with DM who underwent AVF surgery in our clinic due to end-stage renal disease were retrospectively included in this study. The patients who could receive hemodialysis were determined as Group 1, and those who could not were determined as Group 2.
RESULTS: A total of 189 patients were included in the study. Those who did not develop AVF primary failure were included in Group 1 [n=138, median age = 59 (22-77) years], and those who did were included in Group 2 [n=51, median age = 63 (20-81) years]. In the multivariate analysis, age >70 years (OR: 0.871, 95% CI: 0.594-0.983, p=0.039), the presence of PAD (OR: 0.582, 95% CI: 0.0.458-0.896, p=0.046), and TyG index (OR: 0.879, 95% CI: 0.591-0.916, p<0.001) were determined as independent predictors for primary AVF failure.
CONCLUSIONS: This study demonstrated that the TyG index value, calculated from blood samples taken at the time of hospital admission in hemodialysis patients with diabetes mellitus (DM), is an independent predictor of primary AVF failure following AVF surgery.
摘要：
目的：动静脉内瘘（AVF）结构是用于血液透析的重要结构。糖尿病（DM）是影响血管系统的危重疾病。甘油三酯葡萄糖（TyG）指数已被证明与2型DM患者的主要不良心血管事件有关。在这项研究中,我们旨在探讨TyG指数对糖尿病患者原发性AVF通畅性的影响.
方法：在2018年3月至2023年3月之间，回顾性研究了因终末期肾脏疾病在我们诊所接受AVF手术的DM患者。可以接受血液透析的患者被确定为第1组，不能接受血液透析的患者被确定为第2组。
结果：共189名患者纳入研究。未发生AVF原发性衰竭的患者被纳入第1组[n=138，中位年龄=59（22-77）岁]，和那些包括在第2组[n=51,中位年龄=63(20-81)岁].在多变量分析中，年龄>70岁（OR：0.871，95%CI：0.594-0.983，p=0.039），PAD的存在（OR：0.582，95%CI：0.0.458-0.896，p=0.046），和TyG指数（OR：0.879，95％CI：0.591-0.916，p<0.001）被确定为原发性AVF失败的独立预测因子。
结论：这项研究表明，TyG指数值，根据糖尿病（DM）血液透析患者入院时采集的血液样本计算，是AVF手术后原发性AVF失败的独立预测因子。
方法：在2018年3月至2023年3月之间，回顾性研究了因终末期肾脏疾病在我们诊所接受AVF手术的DM患者。可以接受血液透析的患者被确定为第1组，不能接受血液透析的患者被确定为第2组。
结果：共189名患者纳入研究。未发生AVF原发性衰竭的患者被纳入第1组[n=138，中位年龄=59（22-77）岁]，和那些包括在第2组[n=51,中位年龄=63(20-81)岁].在多变量分析中，年龄>70岁（OR：0.871，95%CI：0.594-0.983，p=0.039），PAD的存在（OR：0.582，95%CI：0.0.458-0.896，p=0.046），和TyG指数（OR：0.879，95％CI：0.591-0.916，p<0.001）被确定为原发性AVF失败的独立预测因子。
结论：这项研究表明，TyG指数值，根据糖尿病（DM）血液透析患者入院时采集的血液样本计算，是AVF手术后原发性AVF失败的独立预测因子。
