Abstract：
Food proteins are considered an ideal source for the identification of bioactive peptides with the potential to intervene in nutrition-related chronic diseases such as cardiovascular disease, obesity, and diabetes. Egg white-derived peptides (EWPs) have been shown to improve glucose tolerance in insulin-resistant rats. However, underlying mechanisms are to be elucidated. Therefore, we hypothesized that EWP exerts a hypoglycemic effect by regulating hepatic glucose homeostasis. Our results showed that 7 weeks of EWP treatment reduced the fasting blood glucose in T2DM mice and the inhibition of the liver gluconeogenic pathway was involved in the mechanisms of actions. Using the untargeted metabolomics technique, we found that EWP treatment also altered the hepatic metabolic profile in T2DM mice, in which, the role of fatty acid esters of hydroxy fatty acids in mediating the hypoglycemic effect of EWPs might be pivotal.
摘要：
食物蛋白被认为是鉴定生物活性肽的理想来源，有可能干预与营养相关的慢性疾病，如心血管疾病。肥胖，和糖尿病。蛋清衍生肽（EWP）已被证明可以改善胰岛素抵抗大鼠的葡萄糖耐量。然而,潜在的机制有待阐明。因此,我们假设EWP通过调节肝脏葡萄糖稳态发挥降血糖作用.我们的结果表明，EWP治疗7周降低了T2DM小鼠的空腹血糖，并且抑制肝脏糖异生途径参与了作用机制。使用非靶向代谢组学技术，我们发现EWP治疗也改变了T2DM小鼠的肝脏代谢谱，其中，羟基脂肪酸的脂肪酸酯在介导EWPs的降血糖作用中的作用可能是关键的。
