PDF(Pubmed)
Abstract：
An oxygen sensor-mounted fine-needle biopsy tool was used for in vivo measurement of oxygen levels in tumor xenografts. The system provides a means of measuring the oxygen content in harvested tumor tissue from specific locations. Oxygen in human tumor xenografts in a murine model was observed for over 1 min. Tissues were mapped in relation to oxygen tension (pO2) readings and sampled for conventional cytological examination. Careful modeling of the pO2 readings over 60 seconds yielded a diffusion coefficient for oxygen at the sensor tip, providing additional diagnostic information about the tissue before sampling. Oxygen level measurement may provide a useful adjunct to the use of biomarkers in tumor diagnosis.
摘要：
安装有氧气传感器的细针活检工具用于体内测量肿瘤异种移植物中的氧气水平。该系统提供了测量从特定位置收获的肿瘤组织中的氧含量的手段。在鼠模型中观察到人肿瘤异种移植物中的氧超过1分钟。根据氧张力（pO2）读数绘制组织图，并采样以进行常规细胞学检查。在60秒内对pO2读数进行仔细建模，得出了传感器尖端处氧气的扩散系数，在取样前提供关于组织的额外诊断信息。氧水平测量可以为在肿瘤诊断中使用生物标志物提供有用的辅助。
