%0 Journal Article
%T Oxygen Sensor-Guided Fine Needle Biopsy Studies of Human Cancer Xenografts in Mice.
%A McDonald RC
%A Fischer AH
%A Rusckowski M
%J bioRxiv
%V 0
%N 0
%D 2024 Jun 1
%M 38854036
暂无%R 10.1101/2024.05.27.596060
%X An oxygen sensor-mounted fine-needle biopsy tool was used for in vivo measurement of oxygen levels in tumor xenografts. The system provides a means of measuring the oxygen content in harvested tumor tissue from specific locations. Oxygen in human tumor xenografts in a murine model was observed for over 1 min. Tissues were mapped in relation to oxygen tension (pO2) readings and sampled for conventional cytological examination. Careful modeling of the pO2 readings over 60 seconds yielded a diffusion coefficient for oxygen at the sensor tip, providing additional diagnostic information about the tissue before sampling. Oxygen level measurement may provide a useful adjunct to the use of biomarkers in tumor diagnosis.