PDF(Pubmed)
Abstract：
UNASSIGNED: We currently lack a robust noninvasive method to measure prefrontal excitability in humans. Concurrent TMS and EEG in the prefrontal cortex is usually confounded by artifacts. Here we asked if real-time optimization could reduce artifacts and enhance a TMS-EEG measure of left prefrontal excitability.
UNASSIGNED: This closed-loop optimization procedure adjusts left dlPFC TMS coil location, angle, and intensity in real-time based on the EEG response to TMS. Our outcome measure was the left prefrontal early (20-60 ms) and local TMS-evoked potential (EL-TEP).
UNASSIGNED: In 18 healthy participants, this optimization of coil angle and brain target significantly reduced artifacts by 63% and, when combined with an increase in intensity, increased EL-TEP magnitude by 75% compared to a non-optimized approach.
UNASSIGNED: Real-time optimization of TMS parameters during dlPFC stimulation can enhance the EL-TEP.
UNASSIGNED: Enhancing our ability to measure prefrontal excitability is important for monitoring pathological states and treatment response.
UNASSIGNED: This closed-loop optimization procedure adjusts left dlPFC TMS coil location, angle, and intensity in real-time based on the EEG response to TMS. Our outcome measure was the left prefrontal early (20-60 ms) and local TMS-evoked potential (EL-TEP).
UNASSIGNED: In 18 healthy participants, this optimization of coil angle and brain target significantly reduced artifacts by 63% and, when combined with an increase in intensity, increased EL-TEP magnitude by 75% compared to a non-optimized approach.
UNASSIGNED: Real-time optimization of TMS parameters during dlPFC stimulation can enhance the EL-TEP.
UNASSIGNED: Enhancing our ability to measure prefrontal excitability is important for monitoring pathological states and treatment response.
摘要：
■我们目前缺乏一种强大的非侵入性方法来测量人类的前额叶兴奋性。前额叶皮层中并发的TMS和EEG通常被伪影混淆。在这里，我们询问实时优化是否可以减少伪影并增强左前额叶兴奋性的TMS-EEG测量。
■此闭环优化程序调整左dlPFCTMS线圈位置，angle,和强度实时基于脑电图对TMS的反应。我们的结果测量是左前额叶早期（20-60ms）和局部TMS诱发电位（EL-TEP）。
■在18名健康参与者中，这种线圈角度和大脑目标的优化显著减少了63%的伪影，当结合强度的增加，与非优化方法相比，EL-TEP幅度增加了75%。
■在dlPFC刺激期间实时优化TMS参数可以增强EL-TEP。
■增强我们测量前额叶兴奋性的能力对于监测病理状态和治疗反应很重要。
■我们开发了一种实时闭环优化程序，以从dlPFCTMS获得高振幅早期局部TEP（EL-TEP）。线圈角度和大脑目标的顺序优化减少了63％的伪影。线圈角度的顺序优化，大脑目标，强度使EL-TEP振幅增加75%。
■此闭环优化程序调整左dlPFCTMS线圈位置，angle,和强度实时基于脑电图对TMS的反应。我们的结果测量是左前额叶早期（20-60ms）和局部TMS诱发电位（EL-TEP）。
■在18名健康参与者中，这种线圈角度和大脑目标的优化显著减少了63%的伪影，当结合强度的增加，与非优化方法相比，EL-TEP幅度增加了75%。
■在dlPFC刺激期间实时优化TMS参数可以增强EL-TEP。
■增强我们测量前额叶兴奋性的能力对于监测病理状态和治疗反应很重要。
■我们开发了一种实时闭环优化程序，以从dlPFCTMS获得高振幅早期局部TEP（EL-TEP）。线圈角度和大脑目标的顺序优化减少了63％的伪影。线圈角度的顺序优化，大脑目标，强度使EL-TEP振幅增加75%。
