%0 Journal Article
%T Real-time optimization to enhance noninvasive cortical excitability assessment in the human dorsolateral prefrontal cortex.
%A Parmigiani S
%A Cline CC
%A Sarkar M
%A Forman L
%A Truong J
%A Ross JM
%A Gogulski J
%A Keller CJ
%J bioRxiv
%V 0
%N 0
%D 2024 May 31
%M 38853941
暂无%R 10.1101/2024.05.29.596317
%X <B>UNASSIGNED: </B>We currently lack a robust noninvasive method to measure prefrontal excitability in humans. Concurrent TMS and EEG in the prefrontal cortex is usually confounded by artifacts. Here we asked if real-time optimization could reduce artifacts and enhance a TMS-EEG measure of left prefrontal excitability.<BR><B>UNASSIGNED: </B>This closed-loop optimization procedure adjusts left dlPFC TMS coil location, angle, and intensity in real-time based on the EEG response to TMS. Our outcome measure was the left prefrontal early (20-60 ms) and local TMS-evoked potential (EL-TEP).<BR><B>UNASSIGNED: </B>In 18 healthy participants, this optimization of coil angle and brain target significantly reduced artifacts by 63% and, when combined with an increase in intensity, increased EL-TEP magnitude by 75% compared to a non-optimized approach.<BR><B>UNASSIGNED: </B>Real-time optimization of TMS parameters during dlPFC stimulation can enhance the EL-TEP.<BR><B>UNASSIGNED: </B>Enhancing our ability to measure prefrontal excitability is important for monitoring pathological states and treatment response.