Abstract：
Lipids are increasingly being incorporated into delivery systems due to their ability to facilitate intestinal absorption of lipid-soluble nutrients through molecular solubilization and micellization. In this work, self-assembled complexes of ovalbumin (OVA) and nine dietary fatty acids (FAs) were constructed to improve the processability and absorbability of lutein (LUT). Results showed that all FAs could form stable hydrophilic particles with OVA under the optimized ultrasound-coupled pH conditions. Fourier infrared spectroscopy and transmission electron microscopy analysis showed that these binary complexes effectively encapsulated LUT with an encapsulation rate > 90.0 %. Stability experiments showed that these complexes protected LUT well, which could improve thermal stability and in vitro digestive stability by 1.66-3.58-fold and 1.27-2.74-fold, respectively. Besides, the bioaccessibility of LUT was also enhanced by 7.16-24.99-fold. The chain length and saturation of FAs affected the stability and absorption of LUT. Therefore, these results provided some reference for the selection of FAs for efficient delivery of lipid-soluble nutrients.
摘要：
由于脂质能够通过分子溶解和胶束化促进肠吸收脂溶性营养物,因此脂质越来越多地掺入递送系统中。在这项工作中,构建了卵清蛋白（OVA）和9种膳食脂肪酸（FAs）的自组装复合物，以改善叶黄素（LUT）的可加工性和可吸收性。结果表明，在优化的超声耦合pH条件下，所有FAs都能与OVA形成稳定的亲水性颗粒。傅里叶红外光谱和透射电子显微镜分析表明，这些二元配合物有效地包封了LUT，包封率>90.0％。稳定性实验表明,这些配合物很好地保护了LUT,可将热稳定性和体外消化稳定性提高1.66-3.58倍和1.27-2.74倍，分别。此外,LUT的生物可及性也提高了7.16-24.99倍。FAs的链长和饱和度影响LUT的稳定性和吸收。因此,这些结果为选择有效输送脂溶性营养物质的FAs提供了参考。
