Abstract：
To enhance the bioavailability of bioactives with varying efficacy in the gastrointestinal tract (GIT), a co-delivery system of solid-in-oil-in-water (S/O/W) emulsion was designed for the co-encapsulation of two bioactives in this paper. S/O/W emulsions were fabricated utilizing fucoxanthin (FUC)-loaded nanoparticles (NPs) as the solid phase, coconut oil containing curcumin (Cur) as the oil phase, and carboxymethyl starch (CMS)/propylene glycol alginate (PGA) complex as the aqueous phase. The high entrapment efficiency of Cur (82.3-91.3%) and FUC (96.0-96.1%) was found in the CMS/PGA complex-stabilized S/O/W emulsions. Encapsulation of Cur and FUC within S/O/W emulsions enhanced their UV and thermal stabilities. In addition, S/O/W emulsions prepared with CMS/PGA complexes displayed good stability. More importantly, the formed S/O/W emulsion possessed programmed sequential release characteristics, delivering Cur and FUC to the small intestine and colon, respectively. These results contributed to designing co-delivery systems for the programmed sequential release of two hydrophobic nutrients in the GIT.
摘要：
为了提高胃肠道（GIT）中不同功效的生物活性物质的生物利用度，本文设计了一种水包油固体（S/O/W）乳液的共递送系统，用于两种生物活性物质的共包封。S/O/W乳液是利用岩藻黄质（FUC）-负载纳米颗粒（NPs）作为固相制备的，含有姜黄素（Cur）作为油相的椰子油，和羧甲基淀粉(CMS)/海藻酸丙二醇酯(PGA)复合物作为水相。在CMS/PGA复合物稳定的S/O/W乳液中发现了Cur（82.3-91.3％）和FUC（96.0-96.1％）的高包封率。在S/O/W乳液中封装Cur和FUC增强了它们的UV和热稳定性。此外,用CMS/PGA复合物制备的S/O/W乳液显示出良好的稳定性。更重要的是,形成的S/O/W乳液具有程序化的顺序释放特性，将Cur和FUC输送到小肠和结肠，分别。这些结果有助于设计用于GIT中两种疏水性营养素的程序顺序释放的共递送系统。
