Abstract：
Failure of articular cartilage lubrication and inflammation are the main causes of osteoarthritis (OA), and integrated treatment realizing joint lubrication and anti-inflammation is becoming the most effective treat model. Inspired by low friction of human synovial fluid and adhesive chemical effect of mussels, our work reports a biomimetic lubricating system that realizes long-time lubrication, photothermal responsiveness and anti-inflammation property. To build the system, a dopamine-mediated strategy is developed to controllably graft hyaluronic acid on the surface of metal organic framework. The design constructs a biomimetic core-shell structure that has good dispersity and stability in water with a high drug loading ratio of 99%. Temperature of the solution rapidly increases to 55 °C under near-infrared light, and the hard-soft lubricating system well adheres to wear surfaces, and greatly reduces frictional coefficient by 75% for more than 7200 times without failure. Cell experiments show that the nanosystem enters cells by endocytosis, and releases medication in a sustained manner. The anti-inflammatory outcomes validate that the nanosystem prevents the progression of OA by down-regulating catabolic proteases and pain-related genes and up-regulating genes that are anabolic in cartilage. The study provides a bioinspired strategy to employ metal organic framework with controlled surface and structure for friction reduction and anti-inflammation, and develops a new concept of OA synergistic therapy model for practical applications.
摘要：
关节软骨润滑和炎症的失败是骨关节炎（OA）的主要原因，实现关节润滑和抗炎的综合治疗正成为最有效的治疗模式。受人类滑液的低摩擦和贻贝的粘附化学作用的启发，我们的工作报告了实现长时间润滑的仿生润滑系统，光热反应性和抗炎特性。为了建立系统，开发了一种多巴胺介导的策略，以可控地将透明质酸接枝到金属有机框架的表面上。该设计构建了一种具有良好分散性和在水中稳定性的仿生核壳结构,载药率高达99%。在近红外光下，溶液的温度迅速升高至55°C，软硬润滑系统很好地粘附在磨损表面上，并且在不失效的情况下，将摩擦系数大大降低了75％，持续超过7200次。细胞实验表明，纳米系统通过内吞作用进入细胞，并以持续的方式释放药物。抗炎结果证实纳米系统通过下调分解代谢蛋白酶和疼痛相关基因以及上调软骨中合成代谢的基因来防止OA的进展。该研究提供了一种生物启发策略，采用具有受控表面和结构的金属有机框架来减少摩擦和抗炎。并开发了一种新概念的OA协同治疗模型，用于实际应用。
