Abstract：
OBJECTIVE: This study investigated the effect of metabolic syndrome (MetS) on periodontal clinical parameters and salivary biomarkers\' matrix metalloproteinase-8 (MMP-8) and myeloperoxidase (MPO) in patients with periodontitis.
METHODS: A total of 120 participants aged 25-55 were categorized into three groups: MetS with periodontitis (n = 40); systemically healthy with periodontitis (n = 40); and systemically and periodontally healthy controls (n = 40). Data collected included systemic parameters like waist circumference (WC), blood pressure (BP), high- and low-density lipoproteins, triglycerides (TG), fasting blood sugar (FBS), and glycated hemoglobin (HbA1c). Periodontal parameters estimated included bleeding on probing score (BoP), full-mouth plaque score (FMPS), periodontal probing depth (PPD), clinical attachment loss (CAL), and the number of missing teeth. Unstimulated whole saliva was analyzed via ELISA for active MMP-8 (aMMP-8), total MMP-8 (tMMP-8), and MPO.
RESULTS: Participants with MetS and periodontitis exhibited significantly higher periodontal parameters, salivary aMMP-8, and MPO (26.26 vs. 24.1 ng/mL and 13.53 vs. 11.55 ng/mL compared to systemically healthy periodontitis patients) (all p < 0.01). Positive correlations occurred between aMMP-8 and WC, TG, and FBS (p < 0.01), and between MPO and WC, BP, and TG (p < 0.01).
CONCLUSIONS: The positive associations between these biomarkers and metabolic parameters indicate their potential utility for monitoring cardiovascular and glycemic risk in patients with periodontal disease.
METHODS: A total of 120 participants aged 25-55 were categorized into three groups: MetS with periodontitis (n = 40); systemically healthy with periodontitis (n = 40); and systemically and periodontally healthy controls (n = 40). Data collected included systemic parameters like waist circumference (WC), blood pressure (BP), high- and low-density lipoproteins, triglycerides (TG), fasting blood sugar (FBS), and glycated hemoglobin (HbA1c). Periodontal parameters estimated included bleeding on probing score (BoP), full-mouth plaque score (FMPS), periodontal probing depth (PPD), clinical attachment loss (CAL), and the number of missing teeth. Unstimulated whole saliva was analyzed via ELISA for active MMP-8 (aMMP-8), total MMP-8 (tMMP-8), and MPO.
RESULTS: Participants with MetS and periodontitis exhibited significantly higher periodontal parameters, salivary aMMP-8, and MPO (26.26 vs. 24.1 ng/mL and 13.53 vs. 11.55 ng/mL compared to systemically healthy periodontitis patients) (all p < 0.01). Positive correlations occurred between aMMP-8 and WC, TG, and FBS (p < 0.01), and between MPO and WC, BP, and TG (p < 0.01).
CONCLUSIONS: The positive associations between these biomarkers and metabolic parameters indicate their potential utility for monitoring cardiovascular and glycemic risk in patients with periodontal disease.
摘要：
目的：本研究调查了代谢综合征(MetS)对牙周炎患者牙周临床参数和唾液生物标志物基质金属蛋白酶-8(MMP-8)和髓过氧化物酶(MPO)的影响。
方法：将120名年龄在25-55岁之间的参与者分为三组：MetS伴牙周炎（n=40）；全身健康伴牙周炎（n=40）；全身和牙周健康对照（n=40）。收集的数据包括全身参数，如腰围(WC)，血压（BP），高密度和低密度脂蛋白，甘油三酯（TG），空腹血糖（FBS），糖化血红蛋白（HbA1c）。估计的牙周参数包括探查评分（BoP）出血，全口斑块评分（FMPS），牙周探诊深度（PPD），临床附着丧失(CAL)，以及牙齿缺失的数量。通过ELISA分析未刺激的全唾液中的活性MMP-8(aMMP-8),总MMP-8（tMMP-8），MPO。
结果：患有MetS和牙周炎的参与者表现出明显更高的牙周参数，唾液aMMP-8和MPO（26.26vs.24.1ng/mL和13.53vs.11.55ng/mL与全身健康牙周炎患者相比）（所有p<0.01）。aMMP-8与WC呈正相关，TG,和FBS（p<0.01），在MPO和WC之间，BP,和TG(p<0.01)。
结论：这些生物标志物和代谢参数之间的正相关表明它们在监测牙周病患者心血管和血糖风险方面的潜在效用。
方法：将120名年龄在25-55岁之间的参与者分为三组：MetS伴牙周炎（n=40）；全身健康伴牙周炎（n=40）；全身和牙周健康对照（n=40）。收集的数据包括全身参数，如腰围(WC)，血压（BP），高密度和低密度脂蛋白，甘油三酯（TG），空腹血糖（FBS），糖化血红蛋白（HbA1c）。估计的牙周参数包括探查评分（BoP）出血，全口斑块评分（FMPS），牙周探诊深度（PPD），临床附着丧失(CAL)，以及牙齿缺失的数量。通过ELISA分析未刺激的全唾液中的活性MMP-8(aMMP-8),总MMP-8（tMMP-8），MPO。
结果：患有MetS和牙周炎的参与者表现出明显更高的牙周参数，唾液aMMP-8和MPO（26.26vs.24.1ng/mL和13.53vs.11.55ng/mL与全身健康牙周炎患者相比）（所有p<0.01）。aMMP-8与WC呈正相关，TG,和FBS（p<0.01），在MPO和WC之间，BP,和TG(p<0.01)。
结论：这些生物标志物和代谢参数之间的正相关表明它们在监测牙周病患者心血管和血糖风险方面的潜在效用。
