{Reference Type}: Journal Article
{Title}: Association between metabolic syndrome and salivary MMP-8, myeloperoxidase in periodontitis.
{Author}: Thomas JT;Joseph B;Varghese S;Thomas NG;Kamalasanan Vijayakumary B;Sorsa T;Anil S;Waltimo T;
{Journal}: Oral Dis
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 9
{Factor}: 4.068
{DOI}: 10.1111/odi.15014
{Abstract}: <B>OBJECTIVE: </B>This study investigated the effect of metabolic syndrome (MetS) on periodontal clinical parameters and salivary biomarkers' matrix metalloproteinase-8 (MMP-8) and myeloperoxidase (MPO) in patients with periodontitis.<BR><B>METHODS: </B>A total of 120 participants aged 25-55 were categorized into three groups: MetS with periodontitis (n = 40); systemically healthy with periodontitis (n = 40); and systemically and periodontally healthy controls (n = 40). Data collected included systemic parameters like waist circumference (WC), blood pressure (BP), high- and low-density lipoproteins, triglycerides (TG), fasting blood sugar (FBS), and glycated hemoglobin (HbA1c). Periodontal parameters estimated included bleeding on probing score (BoP), full-mouth plaque score (FMPS), periodontal probing depth (PPD), clinical attachment loss (CAL), and the number of missing teeth. Unstimulated whole saliva was analyzed via ELISA for active MMP-8 (aMMP-8), total MMP-8 (tMMP-8), and MPO.<BR><B>RESULTS: </B>Participants with MetS and periodontitis exhibited significantly higher periodontal parameters, salivary aMMP-8, and MPO (26.26 vs. 24.1 ng/mL and 13.53 vs. 11.55 ng/mL compared to systemically healthy periodontitis patients) (all p < 0.01). Positive correlations occurred between aMMP-8 and WC, TG, and FBS (p < 0.01), and between MPO and WC, BP, and TG (p < 0.01).<BR><B>CONCLUSIONS: </B>The positive associations between these biomarkers and metabolic parameters indicate their potential utility for monitoring cardiovascular and glycemic risk in patients with periodontal disease.