Abstract：
High-intensity interval training (HIIT) is a time-efficient, safe, and feasible exercise type that can be utilized across different ages and health status. This randomized cross-over study aimed to investigate the effect of acute HIIT on cortical excitability, M1-related cognitive functions, cognition-related myokines, brain-derived neurotrophic factor (BDNF), and Cathepsin B (CTSB). Twenty-three sedentary young adults (mean age: 22.78 years ± 2.87; 14 female) participated in a cross-over design involving two sessions: either 23 min of HIIT or seated rest. Before and after the sessions, cortical excitability was measured using transcranial magnetic stimulation, and M1-related cognitive functions were assessed by the n-back test and mental rotation test. Serum levels of BDNF and CTSB were assessed using the ELISA method before and after the HIIT intervention. We demonstrated that HIIT improved mental rotation and working memory, and increased serum levels of BDNF and CTSB, whereas cortical excitability did not change. Our findings provide evidence that one session of HIIT is effective on M1-related cognitive functions and cognition-related myokines. Future research is warranted to determine whether such findings are transferable to different populations, such as cognitively at-risk children, adults, and older adults, and to prescribe effective exercise programs.
摘要：
高强度间歇训练(HIIT)是一种省时、安全,和可行的运动类型，可用于不同的年龄和健康状况。这项随机交叉研究旨在研究急性HIIT对皮质兴奋性的影响，M1相关的认知功能，认知相关的肌细胞因子，脑源性神经营养因子(BDNF),和组织蛋白酶B(CTSB)。23名久坐不动的年轻人（平均年龄：22.78岁±2.87；14名女性）参加了涉及两个会议的交叉设计：23分钟的HIIT或坐着休息。在会议之前和之后，使用经颅磁刺激测量皮质兴奋性，通过n-back测验和心理旋转测验评估M1相关的认知功能。在HIIT干预前后使用ELISA方法评估血清BDNF和CTSB的水平。我们证明了HIIT改善了心理旋转和工作记忆，血清BDNF和CTSB水平升高，而皮质兴奋性没有改变。我们的研究结果提供了证据，证明一次HIIT对M1相关的认知功能和认知相关的肌细胞因子有效。未来的研究有必要确定这些发现是否可以转移到不同的人群，比如有认知风险的孩子，成年人,和老年人，并制定有效的锻炼计划。
