Abstract：
A green approach based on simultaneous starch aerogel formation-curcumin impregnation via supercritical fluid technology was used to increase the bioavailability of curcumin. The loading amounts of curcumin were 16.4, 21.4, and 24.9 mg/g of aerogel for the 25% Amyl-loaded, 55% Amyl-loaded, and 72% Amyl-loaded samples, respectively. Curcumin-loaded aerogels showed the eventual distribution of curcumin in the hydrophobic area of the internal structure of the aerogels. In vitro gastrointestinal release profiles demonstrated the enhanced curcumin release from the curcumin-loaded aerogel formulations produced by the SC-CO2 technology over free curcumin. After intestinal digestion, the percentage of released curcumin from 25% Amyl-loaded, 55% Amyl-loaded, and 72% Amyl-loaded was 7.2, 12.1, and 12.1%, respectively, while the release of native curcumin was only 0.5%. Caco-2 cell permeation studies revealed superior bioavailability of curcumin from the curcumin-loaded aerogels. Curcumin-loaded aerogels exhibited improved storage stability than free curcumin.
摘要：
采用基于同时形成淀粉气凝胶的绿色方法-通过超临界流体技术浸渍姜黄素，以提高姜黄素的生物利用度。姜黄素的负载量为16.4、21.4和24.9mg/g气凝胶，55%Amyl-loaded,和72%的淀粉样品，分别。负载姜黄素的气凝胶显示姜黄素最终分布在气凝胶内部结构的疏水区域。体外胃肠道释放曲线表明，与游离姜黄素相比，通过SC-CO2技术生产的姜黄素负载气凝胶制剂中的姜黄素释放增强。肠道消化后，从25%的Amyl负载中释放的姜黄素的百分比，55%Amyl-loaded,72%的Amyl负载分别为7.2、12.1和12.1%，分别,而天然姜黄素的释放量仅为0.5%。Caco-2细胞渗透研究揭示了姜黄素负载气凝胶中姜黄素的优异生物利用度。负载姜黄素的气凝胶表现出比游离姜黄素改善的储存稳定性。
