Abstract：
The decoy receptor interleukin 1 receptor 2 (IL-1R2), also known as CD121b, has different forms: membrane-bound (mIL-1R2), soluble secreted (ssIL-1R2), shedded (shIL-1R2), intracellular domain (IL-1R2ICD). The different forms of IL-1R2 exert not exactly similar functions. IL-1R2 can not only participate in the regulation of inflammatory response by competing with IL-1R1 to bind IL-1 and IL-1RAP, but also regulate IL-1 maturation and cell activation, promote cell survival, participate in IL-1-dependent internalization, and even have biological activity as a transcriptional cofactor. In this review, we provide a detailed description of the biological characteristics of IL-1R2 and discuss the expression and unique role of IL-1R2 in different immune cells. Importantly, we summarize the role of IL-1R2 in immune regulation from different autoimmune diseases, hoping to provide a new direction for in-depth studies of pathogenesis and therapeutic targets in autoimmune diseases.
摘要：
诱骗受体白细胞介素1受体2(IL-1R2),也称为CD121b，具有不同的形式：膜结合（mIL-1R2），可溶性分泌型（ssIL-1R2），脱落（shIL-1R2），胞内结构域(IL-1R2ICD)。不同形式的IL-1R2发挥不完全相似的功能。IL-1R2不仅可以通过与IL-1R1竞争结合IL-1和IL-1RAP参与炎症反应的调节,但也调节IL-1成熟和细胞活化，促进细胞存活,参与IL-1依赖性内化，甚至具有作为转录辅因子的生物活性。在这次审查中,本文详细介绍了IL-1R2的生物学特性,并讨论了IL-1R2在不同免疫细胞中的表达及独特作用。重要的是,我们总结了IL-1R2在不同自身免疫性疾病的免疫调节中的作用,为自身免疫性疾病的发病机制和治疗靶点的深入研究提供新的方向。
