Abstract：
Intermediate filaments (IFs) are integral to the cell cytoskeleton, supporting cellular mechanical stability. Unlike other cytoskeletal components, the detailed structure of assembled IFs has yet to be resolved. This review highlights new insights, linking the complex IF hierarchical assembly to their mechanical properties and impact on cellular functions. While we focus on vimentin IFs, we draw comparisons to keratins, showcasing the distinctive structural and mechanical features that underlie their unique mechanical responses.
摘要：
中间丝（IF）是细胞骨架的组成部分，支持细胞机械稳定性。与其他细胞骨架成分不同，组装的IFs的详细结构尚未解决。这篇评论强调了新的见解，将复杂的IF分层装配与它们的机械性能和对细胞功能的影响联系起来。虽然我们专注于波形蛋白IF，我们与角蛋白进行比较，展示了独特的结构和机械特征，这些特征是其独特的机械响应的基础。
