PDF(Pubmed)
Abstract：
This meta-analysis aimed to describe the efficacy of bumetanide in improving infarct volume, brain edema, and behavioral outcomes in animal models of cerebral ischemia. Embase, PubMed and Web of Science databases were searched from their inception to February 2024 (INPLASY:202430023). Data on the animal species, stroke model, drug dose, time of treatment, method of administration, study quality, and outcomes were extracted and pooled in a meta-analysis. The combined standardized mean difference (SMD) or mean difference (MD) estimates and 95% confidence intervals (CIs) were calculated using random- or fixed-effects models. Thirteen eligible studies involving >200 animals fulfilled the inclusion criteria and were included in this meta-analysis. Meta-analyses demonstrated that bumetanide treatment significantly reduced cerebral infarct volume (SMD: -0.42; 95% CI: -0.75, -0.09; p < 0.01; n = 186 animals) and consistently relieved brain edema (SMD: -1.39; 95% CI: -2.06, -0.72; p < 0.01; n = 64 animals). Subgroup analyses demonstrated that bumetanide treatment reduced infarct volume in transient but not permanent cerebral ischemia models. When administered after the stroke, it was more effective than treatment initiation before the stroke. Eight studies assessed the effect of bumetanide on behavioral function and the results showed that bumetanide treatment significantly improved neurobehavioral deficits (SMD: -2.35; 95% CI: -2.72, -1.97; p < 0.01; n = 250 animals). We conclude that bumetanide appears to be effective in reducing infarct volume and brain edema and improving behavioral recovery in animal models of cerebral ischemia. This mechanism needs to be confirmed through further investigation.
摘要：
这项荟萃分析旨在描述布美他尼改善梗死体积的疗效。脑水肿,脑缺血动物模型的行为结果。Embase,检索PubMed和WebofScience数据库从成立到2024年2月(文件编号:202430023)。关于动物物种的数据，中风模型,药物剂量，治疗时间,管理方法,学习质量,和结果被提取并汇集在荟萃分析中.使用随机或固定效应模型计算组合的标准化平均差（SMD）或平均差（MD）估计值和95％置信区间（CI）。涉及>200只动物的13项符合条件的研究符合纳入标准，并纳入本荟萃分析。荟萃分析表明，布美他尼治疗可显着降低脑梗死体积（SMD：-0.42；95％CI：-0.75，-0.09；p<0.01；n=186只动物），并持续减轻脑水肿（SMD：-1.39；95％CI：-2.06，-0.72；p<0.01；n=64只动物）。亚组分析表明，布美他尼治疗可减少短暂性而非永久性脑缺血模型的梗死体积。当中风后给药时，它比中风前开始治疗更有效.8项研究评估了布美他尼对行为功能的影响，结果表明布美他尼治疗可显着改善神经行为缺陷（SMD：-2.35；95％CI：-2.72，-1.97；p<0.01；n=250只动物）。我们得出的结论是，布美他尼在脑缺血动物模型中似乎可有效减少梗死体积和脑水肿并改善行为恢复。这种机制需要通过进一步的调查来证实。
