Abstract：
The oceans are rich in diverse microorganisms, animals, and plants. This vast biological complexity is a major source of unique secondary metabolites. In particular, marine fungi are a promising source of compounds with unique structures and potent antibacterial properties. Over the last decade, substantial progress has been made to identify these valuable antibacterial agents. This review summarizes the chemical structures and antibacterial activities of 223 compounds identified between 2012 and 2023. These compounds, effective against various bacteria including drug-resistant strains such as methicillin-resistant Staphylococcus aureus, exhibit strong potential as antibacterial therapeutics. The review also highlights the relevant challenges in transitioning from drug discovery to product commercialization. Emerging technologies such as metagenomics and synthetic biology are proposed as viable solutions. This paper sets the stage for further research on antibacterial compounds derived from marine fungi and advocates a multidisciplinary approach to combat drug-resistant bacteria.
摘要：
海洋富含多种微生物，动物,和植物。这种巨大的生物复杂性是独特的次生代谢物的主要来源。特别是,海洋真菌是具有独特结构和有效抗菌性能的化合物的有前途的来源。在过去的十年里，在鉴定这些有价值的抗菌剂方面已经取得了实质性进展。本文总结了2012年至2023年之间鉴定的223种化合物的化学结构和抗菌活性。这些化合物,有效对抗各种细菌，包括耐甲氧西林金黄色葡萄球菌等耐药菌株，表现出作为抗菌疗法的强大潜力。该评论还强调了从药物发现向产品商业化过渡的相关挑战。宏基因组学和合成生物学等新兴技术被提出作为可行的解决方案。本文为进一步研究源自海洋真菌的抗菌化合物奠定了基础，并倡导采用多学科方法来对抗耐药细菌。
