Abstract：
Previous studies have demonstrated that exposure to polycyclic aromatic hydrocarbons (PAHs) can affect maternal and infant health. However, the conclusions regarding the effects of seasonal PAH exposure on maternal and infant health have been inconsistent. To further elucidate this issue, this study included data from 2282 mother-infant pairs in the Zuni birth cohort. The objective was to investigate the association between maternal late-pregnancy urinary PAH metabolite concentrations and neonatal birth outcomes during the heating and non-heating seasons. The results demonstrated that PAH exposure in Zunyi was primarily dominated by 2-OHNAP and 1-OHNAP and that the concentrations of PAH metabolites were significantly higher during the heating season. Furthermore, PAH metabolite exposure was found to affect neonatal birth weight, birth length, and parity index with seasonal differences. Further dose-effect analyses revealed nonlinear relationships and seasonal differences between PAH metabolites and neonatal birth weight, birth length, and parity index. Bayesian kernel mechanism regression modeling demonstrated that the inverted U-shaped relationship between PAH metabolites and neonatal birth weight and parity index was exclusive to the heating season. Consequently, it can be posited that maternal exposure to PAH metabolites during late pregnancy exerts a detrimental influence on neonatal growth and development, which is further compounded by the use of heating fuels. This highlights the necessity to either control or alter the use of heating fuels during pregnancy.
摘要：
先前的研究表明，接触多环芳烃（PAHs）会影响母婴健康。然而,关于季节性PAH暴露对母婴健康影响的结论不一致.为了进一步阐明这个问题，这项研究纳入了Zuni出生队列中2282对母婴的数据.目的是调查孕妇妊娠晚期尿PAH代谢物浓度与加热和非加热季节新生儿出生结局之间的关系。结果表明，遵义的PAH暴露主要以2-OHNAP和1-OHNAP为主，并且在供暖季节PAH代谢产物的浓度显着升高。此外，发现PAH代谢物暴露会影响新生儿出生体重，出生长度,和平差指数具有季节性差异。进一步的剂量效应分析揭示了PAH代谢物与新生儿出生体重之间的非线性关系和季节性差异，出生长度,和平价指数。贝叶斯核机制回归模型表明，PAH代谢产物与新生儿出生体重和胎次指数之间的倒U型关系是采暖季节所独有的。因此,可以认为，孕妇在妊娠晚期暴露于PAH代谢物会对新生儿的生长和发育产生不利影响，加热燃料的使用进一步加剧了这种情况。这凸显了在怀孕期间控制或改变加热燃料使用的必要性。
